PMID: 9440311Jan 24, 1998Paper

UV induced erythema evaluated 24 h post-exposure by skin reflectance and laser Doppler flowmetry is identical in healthy persons and patients with cutaneous malignant melanoma and basal cell cancer

Journal of Photochemistry and Photobiology. B, Biology
J Lock-AndersenH C Wulf

Abstract

Twenty-one patients with invasive cutaneous malignant melanoma and 19 patients with basal cell skin cancer and 29 healthy volunteers were phototested on non-UV exposed buttock skin to examine their 24 h reaction to a series of increasing doses of simulated sunlight with 25% dose increments. Skin pigmentation at the phototest sites was determined by skin reflectance before testing to assure an equal level of constitutive skin pigmentation in the 3 groups. Erythema reactions were scored visually 24 hours post-exposure and objective measurements of erythema were performed by skin reflectance and laser Doppler flowmetry. In adjacent non-irradiated skin the redness was also quantified to determine the increase in redness in irradiated skin compared to non-irradiated skin. Constitutional skin pigmentation correlated well to UV sensitivity (r = 0.75) and skin redness measured by skin reflectance technique correlated to laser Doppler flowmetry (r = 0.86). No significant differences in UV doses to barely perceptible erythema or to the higher erythema grades were found between the two skin tumour groups and the control group, and no significant differences were found in skin reflectance measured redness or in laser Doppler flowmetry of a...Continue Reading

References

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Aug 1, 1996·Photodermatology, Photoimmunology & Photomedicine·J Lock-Andersen, H C Wulf

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Citations

Sep 25, 1998·The British Journal of Dermatology·F De Fine OlivariusM Norval
Jun 25, 1998·Photodermatology, Photoimmunology & Photomedicine·J Lock-AndersenN D Knudstorp
Apr 5, 2001·The Journal of Investigative Dermatology·R NaH C Wulf
Feb 20, 2002·The Journal of Investigative Dermatology·Chunyan ZhaoKari Hemminki
Jul 9, 2004·Photodermatology, Photoimmunology & Photomedicine·M HenriksenH C Wulf
Oct 22, 2008·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·M FalkC Anderson
Jul 3, 2013·Photodermatology, Photoimmunology & Photomedicine·Mette BodekærHans Christian Wulf
Oct 21, 2006·Journal of the American Academy of Dermatology·Elisabeth A HolmGregor B E Jemec

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