UV-induced immunosuppressive and anti-inflammatory actions: mechanisms and clinical applications

Immunotherapy
Etienne Dupont, Ligia Craciun

Abstract

The introduction in 1974 of psoralens UVA (PUVA) therapy followed in 1987 by extracorporeal photopheresis (ECP) has launched UV light in medicine field. A significant number of potential mechanisms could be linked to the basic cellular UV action (i.e., DNA damage and subsequent cells apoptosis). Phagocytosis by macrophages and dendritic cells (DCs) leads, through a receptor-mediated process, to their modulation. A state of antigen-specific tolerance is induced by induction of Treg cells, inhibition of DCs, which remain at a an immature state, inhibition of production of the proinflammatory cytokines IL-2, IFN-gamma, TNF-alpha and IL-12, and induction of production of cytokines IL-10, TGF-beta and IL-1Ra. Beside cutaneous T-cell lymphoma, use of ECP remains experimental except for graft-versus-host disease, especially the chronic-resistant form. The sparing action of corticosteroids as described in studies on transplantation deserves further attention.

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Citations

Mar 1, 2012·Human Reproduction Update·P ViganòM Candiani
Feb 22, 2012·Diabetes/metabolism Research and Reviews·Sakineh Shab-BidarA'azam Gharavi
Nov 1, 2011·Immunity·Thomas S Griffith, Thomas A Ferguson
Oct 5, 2017·Future Oncology·Praveen K Bommareddy, Howard L Kaufman
Nov 7, 2017·Photochemistry and Photobiology·Keiichi HiramotoSatoshi Yokoyama

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