UV photofunctionalization promotes nano-biomimetic apatite deposition on titanium

International Journal of Nanomedicine
Makiko SaitaTakahiro Ogawa

Abstract

Although biomimetic apatite coating is a promising way to provide titanium with osteoconductivity, the efficiency and quality of deposition is often poor. Most titanium implants have microscale surface morphology, and an addition of nanoscale features while preserving the micromorphology may provide further biological benefit. Here, we examined the effect of ultraviolet (UV) light treatment of titanium, or photofunctionalization, on the efficacy of biomimetic apatite deposition on titanium and its biological capability. Micro-roughed titanium disks were prepared by acid-etching with sulfuric acid. Micro-roughened disks with or without photofunctionalization (20-minute exposure to UV light) were immersed in simulated body fluid (SBF) for 1 or 5 days. Photofunctionalized titanium disks were superhydrophilic and did not form surface air bubbles when immersed in SBF, whereas non-photofunctionalized disks were hydrophobic and largely covered with air bubbles during immersion. An apatite-related signal was observed by X-ray diffraction on photofunctionalized titanium after 1 day of SBF immersion, which was equivalent to the one observed after 5 days of immersion of control titanium. Scanning electron microscopy revealed nodular apati...Continue Reading

Citations

May 12, 2016·The Journal of Oral Implantology·Dennis Flanagan
Jan 23, 2020·International Journal of Molecular Sciences·Hiroaki KitajimaTakahiro Ogawa
Sep 14, 2018·ACS Applied Materials & Interfaces·Arghya K BishalChristos G Takoudis

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BETA
scanning electron microscopy
X-ray
enzyme-linked immunosorbent assay
ELISA

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