PMID: 11604261Oct 18, 2001Paper

UV-spectrophotometry study of membrane transport processes with a novel diffusion cell

International Journal of Pharmaceutics
K T KierstanA F Davis

Abstract

A novel diffusion cell has been constructed which allows study of membrane diffusion processes without the need for sampling of the receiver compartment, that is highly sensitive and, being based around a diode array spectrophotometer also allows for continuous, real-time recording of multi-species concentration changes in the receiving compartment. The system is controlled to operate isothermally (via a Peltier control system) at temperatures between 15 and 85 degrees C. To examine the performance of this novel design, the transfer of tetracaine from a preparation in PEG 400 (20% tetracaine in PEG 400) has been studied. The results have been used to determine flux, lag time and related parameters. The performance of the novel cell is compared with results from traditional Franz cell diffusion studies.

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Citations

Oct 26, 2010·Analytical and Bioanalytical Chemistry·Vanessa Castro-LópezAnthony J Killard
Mar 12, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·M E MoralesM A Ruiz
Feb 27, 2010·Drug Development and Industrial Pharmacy·M E MoralesV Gallardo
Apr 29, 2015·International Journal of Cosmetic Science·P ThataiB Sapra
Feb 15, 2005·International Journal of Pharmaceutics·I CsókaI Eros
Nov 14, 2006·International Journal of Pharmaceutics·M MohorcicS Murdan
Aug 2, 2014·Toxicology in Vitro : an International Journal Published in Association with BIBRA·A FrankenJ L Du Plessis
Dec 12, 2012·Carbohydrate Polymers·María Jesús LuceroMaría Rosa Jiménez-Castellanos
Dec 20, 2014·Toxicology Letters·A FrankenJ L Du Plessis
Oct 5, 2018·ACS Applied Materials & Interfaces·Roi RutenbergElena Poverenov

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