UVA/riboflavin collagen crosslinking stiffening effects on anterior and posterior corneal flaps

Experimental Eye Research
Hamed Hatami-Marbini, Sandeep M Jayaram

Abstract

The UVA/riboflavin collagen crosslinking (CXL) is one of the treatment procedure for stopping the progression of keratoconus. The inclusion criterion for this procedure is a minimum corneal thickness of 400 μm, which is not often met in patients with advanced keratoconus. Preoperatively swelling thin corneas was shown to stabilize the keratectasia without any postoperative endothelial damage. Recently, we have shown that swelling porcine corneas prior to the CXL treatment had no significant effect on the resulting improvement in their tensile properties. In the present study, we extended this previous study and characterized the stiffening effects of CXL on anterior and posterior flaps as a function of their hydration. A DSAEK system was used to excise 10 mm corneal flaps from 80 porcine corneas. Individual flaps were crosslinked at different initial hydration levels by using riboflavin solutions composed of different dextran concentrations; the thickness was taken as a measure of flap hydration. A DMA machine was used to measure the tensile properties either immediately after the CXL treatment or after the thickness (hydration) of the crosslinked samples was brought down to a specific value. The average thickness of anterior g...Continue Reading

Citations

May 31, 2019·Journal of Cataract and Refractive Surgery·Theo G Seiler, Theo Seiler
Jul 16, 2020·Scientific Reports·A Ashofteh YazdiG Rus
Dec 20, 2019·Translational Vision Science & Technology·Yuan WuXiaoming Yan
Mar 9, 2021·American Journal of Ophthalmology Case Reports·Sila Bal, Joseph B Ciolino

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