PMID: 2497190May 1, 1989Paper

UVB-induced melanogenesis may be mediated through the MSH-receptor system

The Journal of Investigative Dermatology
J L BologniaJ M Pawelek

Abstract

Ultraviolet B radiation (UVB) elicits an increase in melanin production in mammalian skin. The mechanisms regulating this process are not understood, although it is well documented that there is an increase in the number of melanin-producing melanocytes. The melanotropins (MSH) are a family of peptides that increase the melanin content of melanocytes through an interaction with high affinity receptors. We have obtained evidence that the effects of UVB on melanogenesis may be mediated through an increase in MSH receptor activity on melanocytes. First, exposure of Cloudman S91 mouse melanoma cells to UVB resulted in increased binding of 125I-MSH to cells within 24 h. In five separate experiments, UVB-irradiated cultures displayed 2-10-fold increases in MSH binding capacity over that of unirradiated control cultures (optimum doses 10-20 mJ/cm2). Second, UVB and MSH potentiated one another in promoting cutaneous melanogenesis in both mice and guinea pigs. In the areas of guinea pig skin that received both UVB and MSH, there was a fivefold increase in active melanocytes/mm2 over the sum of active melanocytes/mm2 in areas receiving either MSH or UVB separately. Our results suggest that UVB light causes an increase in MSH receptor act...Continue Reading

Citations

Oct 1, 1994·Pigment Cell Research·J L BologniaJ M Pawelek
May 1, 1993·In Vitro Cellular & Developmental Biology. Animal·S SuzukiT Takeuchi
May 31, 1993·Annals of the New York Academy of Sciences·M E HadleyR T Dorr
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May 9, 2014·Pigment Cell & Melanoma Research·Jose C García-BorrónCelia Jiménez-Cervantes
Jan 1, 1996·Photochemistry and Photobiology·B A GilchrestM Yaar
Mar 1, 1991·Pigment Cell Research·J M Pawelek
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Sep 1, 1990·Pigment Cell Research·J L BologniaJ M Pawelek
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Mar 29, 2003·Veterinary Dermatology·Shola S Sulaimon, Barbara E Kitchell

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