UVB irradiation-induced transcription from the long terminal repeat of intracisternal A particles and UVB-induced secretion of an extracellular factor that induces transcription of the intracisternal A particles in unirradiated cells

Journal of Photochemistry and Photobiology. B, Biology
E FaureS Champion

Abstract

Intracisternal A particles (IAPs) are endogenous defective retroviral-like elements encoded by a family of proviral sequences present as a thousand copies in the mouse genome. In order to analyse the regulation of the long terminal repeat (LTR) directed transcription by UVB, D152 murine cells were transfected with a chimeric construct carrying the LTR of IAP linked to the bacterial chloramphenicol-acetyl-transferase reporter gene and then subjected by UVB irradiation in a dose- and time-dependent manner. Like the human immunodeficiency virus 1 type LTR and in spite of the lack of the nuclear factor kappa B consensus sequence, the IAP LTR could be activated by UVB. In addition, the D152 cells produced an extracellular factor are factors in response to UVB irradiation which activated the IAP LTR in unirradiated cells. This factor was detected both when responding cells were cocultured with inducing cells and when conditioned medium from irradiated cultures was added to the cell cultures.

References

May 1, 1978·Biophysical Journal·U K EhmannE C Friedberg
Feb 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·M J Curcio, D J Garfinkel
Dec 1, 1990·Photochemistry and Photobiology·B Z Zmudzka, J Z Beer
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·C S LinD Samols
Aug 15, 1990·Journal of the National Cancer Institute·M Pollak, M Richard
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S Munro, T Maniatis
Apr 27, 1989·Nature·W R Brown
Sep 1, 1989·Molecular & General Genetics : MGG·V A Bradshaw, K McEntee
Jan 1, 1988·Advances in Cancer Research·E L Kuff, K K Lueders
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·S E Tong-StarksenB M Peterlin
Jan 1, 1984·Journal of Cellular Physiology. Supplement·I B WeinsteinA Jeffrey
May 1, 1982·Cell·J W Little, D W Mount
Jun 1, 1994·Chemico-biological Interactions·E Vicenzi, G Poli

❮ Previous
Next ❯

Citations

May 17, 2013·Genes & Genetic Systems·Yi-Deun JungHeui-Soo Kim

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.