UVB radiation-mediated inhibition of contact hypersensitivity reactions is dependent on the platelet-activating factor system.

The Journal of Investigative Dermatology
Qiwei ZhangJeffrey B Travers

Abstract

Through its ability to both induce immunosuppression and act as a carcinogen, UVB radiation plays a major role in cutaneous malignancies. Recent studies have indicated that UVB-mediated inhibition of delayed-type hypersensitivity reactions is mediated, in part, by the lipid mediator platelet-activating factor (PAF). The objective of this study was to further define the mechanism by which UVB inhibits contact hypersensitivity (CHS) reactions. UVB irradiation resulted in an inhibition of subsequent CHS to the chemical DNFB in wild-type, but not in PAF-R-deficient mice. UVB-mediated inhibition of CHS was also blocked by a cyclooxygenase-2 (COX-2) inhibitor or a neutralizing antibody directed against IL-10. UVB irradiation upregulated IL-10 mRNA levels in lymph nodes and spleen only to significant levels in PAF-R-expressing mice. Bone marrow transplantation studies demonstrated that UVB-mediated immunomodulatory effects were dependent on PAF-R-positive bone marrow. These studies suggest that UVB irradiation results in epidermal production of PAF agonists, which then act on PAF-R-positive bone marrow-derived cells to upregulate IL-10 through COX-2-generated prostaglandins.

References

Jan 1, 1984·Progress in Lipid Research·E N Frankel
May 15, 1997·The Journal of Clinical Investigation·H A LehrT M McIntyre
Jun 10, 1998·The Journal of Investigative Dermatology·D PeusM R Pittelkow
Jun 27, 2000·Archives of Dermatological Research·C AlappattJ B Travers
Aug 18, 2000·Free Radical Biology & Medicine·G K MaratheT M McIntyre
Aug 31, 2000·Annual Review of Biochemistry·S M PrescottT M McIntyre
Jan 24, 2002·The Journal of Experimental Medicine·Jeffrey P WalterscheidDat X Nghiem
Feb 28, 2002·Frontiers in Bioscience : a Journal and Virtual Library·Stephen E Ullrich
Mar 5, 2002·The Journal of Investigative Dermatology·Jeffrey E PetersenMary C Dinauer
Sep 17, 2002·The Journal of Investigative Dermatology·Dat X NghiemStephen E Ullrich
Mar 4, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Robert P CarrollPaul N Harden
Mar 8, 2005·Mutation Research·Stephen E Ullrich
Aug 24, 2005·The Journal of Biological Chemistry·Gopal K MaratheJeffrey B Travers
Dec 29, 2005·The Journal of Experimental Medicine·Qun ZhaoYusen Liu
Oct 12, 2007·The Journal of Investigative Dermatology·Jeffrey B TraversRaymond L Konger

❮ Previous
Next ❯

Citations

Feb 4, 2012·The Journal of Biological Chemistry·Yongxue YaoJeffrey B Travers
May 25, 2010·Photochemistry and Photobiology·Jared B TraversJeffrey B Travers
Jan 4, 2012·Photochemistry and Photobiology·Ravi P SahuJeffrey B Travers
Jan 16, 2015·Molecular Neurobiology·Ana Catarina MenezesAndreia Ascenso
Jul 23, 2014·The Journal of Investigative Dermatology·Matheus FerraciniJeffrey B Travers
Dec 16, 2011·The Journal of Investigative Dermatology·Stephen E Ullrich, Scott N Byrne
May 29, 2009·The Journal of Investigative Dermatology·Kazuyo KanekoSusan L Walker
Jun 17, 2008·Prostaglandins & Other Lipid Mediators·Raymond L KongerJeffrey B Travers
Sep 25, 2009·The British Journal of Dermatology·G M Murphy
Apr 30, 2015·Mediators of Inflammation·Ravi P SahuJeffrey B Travers
Jun 7, 2011·The American Journal of Pathology·Sabita RanaGary Mark Halliday
Feb 16, 2016·Photochemistry and Photobiology·Ji C BihlJeffrey B Travers
Jan 6, 2017·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Jörg ReichrathThomas Vogt
Feb 6, 2017·Scientific Reports·Elisabetta DamianiStephen E Ullrich
Mar 10, 2016·Oncotarget·Ravi P SahuJeffrey B Travers
Feb 4, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rui ChenThomas M McIntyre
Jan 29, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ravi P SahuJeffrey B Travers
Oct 14, 2018·International Journal of Molecular Sciences·Eric RomerRavi P Sahu
Jun 20, 2017·Integrative Cancer Therapies·Anita Thyagarajan, Ravi P Sahu
Feb 24, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yongxue YaoJeffrey B Travers
Jan 11, 2017·BioMed Research International·D H González MaglioJ Leoni
Apr 3, 2021·Frontiers in Endocrinology·Jeffrey B TraversRavi P Sahu
Jul 30, 2021·Photochemistry and Photobiology·Pariksha ThapaJeffrey B Travers

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

The Journal of Immunology : Official Journal of the American Association of Immunologists
Yongxue YaoJeffrey B Travers
The Journal of Immunology : Official Journal of the American Association of Immunologists
Ravi P SahuJeffrey B Travers
© 2021 Meta ULC. All rights reserved