Uveal lymphoid infiltration. Report of four cases and clinicopathologic review

Ophthalmology
H E GrossniklausN A Rao

Abstract

The purpose of the study was to report the clinicopathologic features of four patients with uveal lymphoid infiltration who were diagnosed by a conjunctival biopsy. A case series. Four patients at four institutions participated. The histopathologic findings of the conjunctival and episcleral biopsy specimens from four patients with the diagnosis of uveal lymphoid infiltration were recorded. The conjunctival specimens were placed in 10% neutral buffered formaldehyde solution or B5 solution and processed routinely for light microscopic examination and immunohistochemical analysis for B cells and T cells and kappa and lambda light chains. The clinical and histopathologic findings were compared with 47 previously reported cases of uveal lymphoid infiltration. Two men and two women (average age = 57 years) presented with diffuse punctate to coalescent yellow uveal infiltrates and epibulbar pink fleshy lesions. Ultrasonography of the lesions showed diffuse choroidal thickening and a lack of choroidal or scleral excavation. The conjunctival biopsy specimens showed diffuse infiltration of the substantia propria with B lymphocytes with variable kappa and lambda restriction. Scattered T lymphocytes also were present. Plasmacytoid cells a...Continue Reading

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Citations

Jul 13, 2002·The Journal of Pathology·Sarah E CouplandHarald Stein
Apr 5, 2005·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Sarah E CouplandHarald Stein
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Mar 19, 2021·Ocular Immunology and Inflammation·Fernando TrejoAntonio Segura
Aug 20, 2021·Current Opinion in Ophthalmology·Kareem Moussa, Lesley Everett

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