PMID: 2117971Aug 1, 1990Paper

Uveal malignant melanoma and optic nerve glioma in von Recklinghausen's neurofibromatosis

The British Journal of Ophthalmology
C M AntleJ Rootman

Abstract

A case of uveal malignant melanoma and contralateral optic nerve glioma is described in a 53-year-old Caucasian male with multiple uveal melanocytic hamartomas and neurofibromatosis. The eye was enucleated, and histologically the melanoma was found to consist of 70% epithelioid cells, with many bizarre, multinucleated forms. CT scan demonstrated a non-enhancing, fusiform enlargement of the contralateral optic nerve with enlargement of the optic canal and intracranial extension. This combination of tumours has not previously been reported in a patient with neurofibromatosis and serves to emphasise the common neuroectodermal origin of tumours in this autosomal dominant condition.

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Citations

Nov 30, 2000·Survey of Ophthalmology·S G HonavarR C Eagle
Nov 20, 2008·Retina·Saad ShaikhJames C Lai
Apr 5, 2013·PloS One·Mugdha DeoCatherine D Van Raamsdonk
Mar 1, 1992·World Journal of Surgery·R F Kefford
Jun 29, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kristof HardaGabor Halmos

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