Uveal Melanoma Biopsy: A Review

Cancers
Luisa FrizzieroRaffaele Parrozzani

Abstract

Intraocular tumor diagnosis is based on clinical findings supported by additional imaging tools, such as ultrasound, optical coherence tomography and angiographic techniques, usually without the need for invasive procedures or tissue sampling. Despite improvements in the local treatment of uveal melanoma (UM), the prevention and treatment of the metastatic disease remain unsolved, and nearly 50% of patients develop liver metastasis. The current model suggests that tumor cells have already spread by the time of diagnosis, remaining dormant until there are favorable conditions. Tumor sampling procedures at the time of primary tumor diagnosis/treatment are therefore now commonly performed, usually not to confirm the diagnosis of UM, but to obtain a tissue sample for prognostication, to assess patient's specific metastatic risk. Moreover, several studies are ongoing to identify genes specific to UM tumorigenesis, leading to several potential targeted therapeutic strategies. Genetic information can also influence the surveillance timing and metastatic screening type of patients affected by UM. In spite of the widespread use of biopsies in general surgical practice, in ophthalmic oncology the indications and contraindications for tum...Continue Reading

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Citations

Dec 15, 2019·Cancers·Ulrich Pfeffer
Jun 9, 2020·Seminars in Ophthalmology·Mehenaz Hanbazazh, Thaddeus P Dryja
Jun 18, 2021·Journal of Experimental & Clinical Cancer Research : CR·Prisca BustamanteJulia V Burnier
Jul 4, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Edoardo MidenaElisabetta Pilotto
Apr 3, 2021·Ocular Oncology and Pathology·Cristina FonsecaRui Proença
Oct 30, 2021·Clinical & Experimental Ophthalmology·Vivian LinSvetlana Cherepanoff

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Methods Mentioned

BETA
biopsy
biopsies

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