Uveitis in juvenile idiopathic arthritis: recent therapeutic advances

Ophthalmic Research
Jane M Wells, Justine R Smith

Abstract

Uveitis is a common association of juvenile idiopathic arthritis (JIA) that has previously been characterized by poor visual prognosis with limited options for effective treatment. Since corticosteroid treatment is not a preferred long-term option for most patients with this condition, systemic immunosuppressive therapy is frequently employed. The medical options for the treatment of JIA-associated uveitis have recently expanded beyond conventional immunosuppressive drugs to the biological agents. The biological drugs that are most commonly employed for JIA-associated uveitis are the tumor necrosis factor-α inhibitors. Other biological agents that have been used to treat the disease include drugs that target cytokine receptors, lymphocyte antigens and lymphocyte co-stimulation signals. This Mini Review highlights recent developments in the medical treatment of JIA-associated uveitis.

Citations

Jul 30, 2016·Ocular Immunology and Inflammation·Emmett T CunninghamManfred Zierhut
Nov 17, 2017·Advances in Therapy·Ioannis AsproudisAnastasios G Konstas
Oct 15, 2019·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Giovanni ContiCarmelo Fede

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