PMID: 6166317May 1, 1981Paper

Uveitis, vitreous humor, and klebsiella. I. Binding studies with rabbit antisera

The British Journal of Ophthalmology
H AvakianA Ebringer

Abstract

Uveitis occur in a proportion of patients with ankylosing spondylitis, and an increased faecal isolation of the Gram-negative micro-organism Klebsiella pneumoniae has been reported from such patients. Immunological cross-reactivity between K. pneumoniae and bovine vitreous humour has been studied by 2 different antibody binding techniques: I125-labelled antigen binding assay with and without carrier, and beta-galactosidase enzyme-immunoassay. Sera from rabbits immunised with whole klebsiella micro-organisms or klebsiella extracts were found to bind labelled vitreous humour antigens to a greater extent (p less than 0.001) than sera from rabbits immunised with Escherichia coli, Streptococcus pyogenes, and phi X 174 virus or sera from the same rabbits before immunisation. It is suggested klebsiella micro-organisms may carry antigenic determinants which resemble vitreous humour antigens.

References

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Citations

Jun 7, 1984·The New England Journal of Medicine
May 1, 1981·The British Journal of Ophthalmology·J WelshA Ebringer
Oct 1, 1982·The British Journal of Ophthalmology·L MattilaP Terho
Dec 1, 1984·The British Journal of Ophthalmology·A B BeckingsaleA R Rosenthal
Feb 1, 1983·Australian Journal of Ophthalmology·D WakefieldR Penny
Aug 1, 1985·Immunological Reviews·A EbringerT Ptaszynska
Nov 1, 1991·Survey of Ophthalmology·D WakefieldP McCluskey

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