Uveitis: what do we know and how does it help?

Clinical & Experimental Ophthalmology
S Lightman

Abstract

Uveitis essentially means intraocular inflammation and encompasses a wide variety of different disorders. This includes both mild and severe types of inflammation affecting different parts of the eye. Histologically, all uveitis is characterized by an influx of lymphocytes into the affected tissue. In all types these lymphocytes are predominantly of the CD4 type, whether the disorder is mild or blinding, giving no clue as to why. New studies comparing cells in ocular fluids taken from inflamed eyes with different types of inflammation have, for the first time, shown a difference in the cytokine profile, so that in visually benign disease interleukin 10 levels are higher than in those which are blinding.The potential for this in terms of therapy is discussed.

References

Jan 1, 1992·Current Eye Research·S Lightman, H Towler
Dec 14, 1991·Lancet·J V Forrester
Dec 14, 1991·Lancet·S Lightman
Jan 1, 1990·Eye·S Lightman, C C Chan
Apr 15, 1990·American Journal of Ophthalmology·P I MurrayA Kijlstra
Oct 1, 1990·International Ophthalmology·K F Tabbara
May 1, 1986·Archives of Ophthalmology·C C ChanJ J Hooks
May 1, 1986·Ophthalmology·C C ChanT Kuwabara
Jan 1, 1981·Current Eye Research·Y de KozakJ P Faure
Jan 1, 1995·International Ophthalmology Clinics·H M Towler, S Lightman
Sep 1, 1996·The British Journal of Ophthalmology·M S Suttorp-Schulten, A Rothova

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Citations

Jun 11, 2005·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·M D Becker, M Zierhut
Jan 22, 2013·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Fatih Cem GülMetin Özgen
Jan 24, 2013·Drug Design, Development and Therapy·Burak TurgutMetin Özgen
Mar 13, 2012·International Journal of Molecular Sciences·Jing WangShang Li
Aug 1, 2007·Proteomics. Clinical Applications·Franz H GrusNorbert Pfeiffer

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