PMID: 8606784Nov 1, 1995Paper

v- and t-SNAREs in neuronal exocytosis: a need for additional components to define sites of release

Neuropharmacology
T GalliP De Camilli

Abstract

Synaptic vesicle recycling is a specialized form of membrane recycling which takes place in all cells between early endosomes and the plasmalemma. Synaptic vesicles exocytosis is highly regulated and occurs only at presynaptic active zones. In contrast, exocytosis of endosome-derived vesicles of the housekeeping recycling pathway takes place constitutively and throughout the cell surface. Since v- and t-SNAREs play a key role in membrane interactions leading to fusion, unique v- and t-SNAREs may be implicated in synaptic vesicle exocytosis. It was found, however, that the same v-SNAREs of the synaptobrevin family are found both on synaptic vesicles and on endosome-derived vesicles which undergo constitutive fusion. Likewise, t-SNAREs which act as plasmalemmal receptors for synaptic vesicles are not restricted to synaptic active zones. Thus, v- and t-SNAREs interactions may define which organelles can fuse with the plasmalemma, but require additional components to define properties of the exocytotic reaction which are specific for distinct classes of secretory organelles.

References

Feb 13, 1992·European Journal of Pharmacology·J M TrifaróA Rodríguez Del Castillo
Jan 1, 1990·Annual Review of Physiology·P De Camilli, R Jahn
Aug 1, 1994·Trends in Neurosciences·T Söllner, J E Rothman
Sep 10, 1993·Cell·M K BennettR H Scheller
Mar 9, 1994·Annals of the New York Academy of Sciences·G SchiavoC Montecucco
Feb 3, 1995·The Journal of Biological Chemistry·H T McMahon, T C Südhof
Jan 1, 1994·Advances in Second Messenger and Phosphoprotein Research·P GreengardF Valtorta
Oct 1, 1994·Current Opinion in Neurobiology·T F Martin
Mar 17, 1995·The Journal of Biological Chemistry·J T TellamD E James
Feb 1, 1994·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A C Thomas-Reetz, P De Camilli
Jun 9, 1994·Nature·M GeppertT C Südhof
Nov 3, 1994·Nature·J E Rothman
Dec 15, 1994·Nature·J P LianS Ferro-Novick
Nov 30, 1994·Biochemical and Biophysical Research Communications·M MiyazakiY Takai
Jul 21, 1994·Nature·S Ferro-Novick, R Jahn
Apr 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·M K Bennett, R H Scheller
Feb 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·J PevsnerR H Scheller
Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·E P GarciaP De Camilli
Jul 29, 1993·Nature·P De Camilli
Mar 25, 1993·Nature·T SöllnerJ E Rothman

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Citations

Jun 16, 1999·Journal of Neuroscience Research·G GrosseM Bergmann
Apr 25, 2006·Cellular and Molecular Neurobiology·Z CaoJ G Townsel
Aug 8, 2002·Neurotoxicology·R M LoPachinE J Lehning
Apr 20, 2000·Neuroscience·S Zakharenko, S Popov
Apr 28, 1999·Neuroscience·I AntonovS V Popov
Aug 23, 2002·Journal of Chemical Neuroanatomy·Yong Ho CheMasaya Tohyama
Aug 1, 1997·Current Opinion in Cell Biology·J C Hay, R H Scheller
Jun 1, 1997·Current Opinion in Neurobiology·P I HansonR Jahn
Apr 22, 2004·Nature Reviews. Neuroscience·Noam E Ziv, Craig C Garner
Oct 10, 1998·The European Journal of Neuroscience·D A RaciborskaM P Charlton
Apr 23, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·F BenfenatiS Giovedí
Dec 23, 2004·Science's STKE : Signal Transduction Knowledge Environment·Thierry Galli, Volker Haucke
Mar 9, 2002·Biochemical and Biophysical Research Communications·Johanna M MaggaJanice E A Braun
Jun 11, 2014·Progress in Neurobiology·Ivica Matak, Zdravko Lacković
Dec 12, 2012·The Journal of Cell Biology·Rhea van de BospoortRuud F Toonen
Apr 14, 2010·The European Journal of Neuroscience·Helen Lee, Nicholas C Brecha
Aug 14, 2003·Biochimica Et Biophysica Acta·Thomas F J Martin
Jul 5, 2001·The Journal of Biological Chemistry·T CoppolaR Regazzi
Sep 15, 2015·PLoS Computational Biology·Alexander UllrichFrank Noé
Sep 12, 2020·Journal of Neurochemistry·Holly MellandSarah L Gordon
Jul 3, 1999·Physiological Reviews·A MeirR Rahamimoff
Jan 29, 1999·Physiological Reviews·C YeamanW J Nelson
Dec 29, 2020·Investigative Ophthalmology & Visual Science·Roland BlumerAngel M Pastor
Jan 8, 2000·The Journal of Biological Chemistry·L S ChinL Li
Dec 26, 2001·Science's STKE : Signal Transduction Knowledge Environment·T Galli, V Haucke

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