PMID: 12770788May 29, 2003Paper

V alpha 24+ natural killer T cells are markedly decreased in atopic dermatitis patients

Human Immunology
Tsuyoshi TakahashiHisamaru Hirai

Abstract

Atopic dermatitis (AD) is a common inflammatory skin disease. In AD, cytokines such as interleukin (IL)-4 or interferon (IFN)-gamma are considered to affect the disease status. Recently, human V alpha 24(+) natural killer T (NKT) cells have been found to produce large amounts of IL-4 and IFN-gamma. Thus there is a possibility that the proportion of V alpha 24(+) NKT cells modifies the AD status. In this study, we examine the proportion of the V alpha 24(+)/V beta 11(+) cells that composes the V alpha 24(+) NKT cells in peripheral blood mononuclear cells (PBMCs) from 71 healthy donors (HDs) and 31 AD patients. Because CD4(-) and CD4(+) NKT subsets show different cytokine production patterns concerning IL-4, these two subsets are evaluated. Our results have shown that the proportion of the V alpha 24(+) NKT cells is markedly reduced in AD patients. In addition, the CD4(-) V alpha 24(+) NKT subset has a tendency to be more reduced than the CD4(+) V alpha 24(+) NKT subset. Moreover, the proportion of CD4(-) V alpha 24(+) NKT(+) cells and Th2 deviation of Th1/Th2 balance is inversely correlated. These observations may contribute to the understanding of the mechanism involved in AD.

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Citations

Jun 22, 2011·Journal of Clinical Immunology·Edit GyimesiAndrea Szegedi
Jul 30, 2009·International Journal of Hematology·Tsuyoshi Takahashi, Mineo Kurokawa
Oct 2, 2007·Journal of Neuroimmunology·Takashi YamamuraSachiko Miyake
Jul 29, 2009·European Journal of Immunology·Sara M LindMikael C I Karlsson
Mar 8, 2014·Immunopharmacology and Immunotoxicology·Maryam RoozbehAbbas Mirshafiey
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Mar 1, 2006·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Sachiko Miyake
Aug 10, 2004·Bone Marrow Transplantation·K HaraguchiH Hirai
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May 7, 2014·Journal of Leukocyte Biology·Sara J McKeeGraham R Leggatt
Jan 12, 2005·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Yasuhiko IkegamiNobuoki Kohno
Sep 6, 2007·Skinmed·Fulya IlhanDemet Cicek
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Oct 24, 2012·Experimental Dermatology·Chang Ook ParkKwang Hoon Lee
Jun 17, 2021·The Journal of Investigative Dermatology·Samantha GenardiChyung-Ru Wang

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