V gamma 1 gammadelta T cells regulate type-1/type-2 immune responses and participate in the resistance to infection and development of heart inflammation in Trypanosoma cruzi-infected BALB/c mice

Microbes and Infection
A NomizoJ Mengel

Abstract

Many different cell populations or lineages participate in the resistance to Trypanosoma cruzi infection. gammadelta T cells may also take part in a network of interactions that lead to control of T. cruzi infection with minimal tissue damage by controlling alphabeta T cell activation, as was previously suggested. However, the gammadelta T cell population is not homogeneous and its functions might vary, depending on T cell receptor usage or distinct stimulatory conditions. In this study, we show that the in vivo depletion of V gamma 1-bearing gammadelta T cells, prior to the infection of BALB/c mice with the Y strain of T. cruzi, induces an increased susceptibility to the infection with lower amounts of IFN-gamma being produced by conventional CD4+ or CD8+ T cells. In addition, the production of IL-4 by spleen T cells in V gamma 1-depleted mice was increased and the production of IL-10 remained unchanged. Since V gamma 1(+) gammadelta T cell depletion diminished the conversion of naive to memory/activated CD4 T cells and the production of IFN-gamma during the acute infection, these cells appear to function as helper cells for conventional CD4+ Th1 cells. Depletion of V gamma 1(+) cells also reduced the infection-induced inflamm...Continue Reading

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Citations

Aug 29, 2014·Mediators of Inflammation·Adriana M C CanavaciAuro Nomizo
Jan 15, 2010·Journal of Cellular and Molecular Medicine·Silvia Beatriz BoscardinAriel Mariano Silber
May 26, 2020·Journal of Leukocyte Biology·Julia Barbalho da MotaAna Carolina Oliveira
Aug 25, 2020·Journal of Medicinal Food·Maísa Carvalho Rezende SoaresRosane Nassar Meireles Guerra

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