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V lambda and J lambda-C lambda gene segments of the human immunoglobulin lambda light chain locus are separated by 14 kb and rearrange by a deletion mechanism

European Journal of Immunology

Jun 1, 1991

G Combriato, H G Klobeck

Abstract

We have cloned a region of 124 kb of the human immunoglobulin lambda light chain locus on chromosome 22 encompassing seven V lambda and seven J-C lambda gene segments. No further C lambda gene segment was found in a region of 35 kb downstream of C lambda 7, which encodes the Ke+Oz- isot...read more

Mentioned in this Paper

Nucleic Acid Hybridization Procedure
Transcription, Genetic
Gene Deletion Abnormality
Immunoglobulin Isotypes
Human normal immunoglobulin
Genome Mapping
Immunoglobulin Light Chains
Partial Monosomy
Pseudogenes
Deletion Mutation
5
2
Paper Details
References
  • References30
  • Citations54
12345...

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V lambda and J lambda-C lambda gene segments of the human immunoglobulin lambda light chain locus are separated by 14 kb and rearrange by a deletion mechanism

European Journal of Immunology

Jun 1, 1991

G Combriato, H G Klobeck

PMID: 1904362

DOI: 10.1002/eji.1830210627

Abstract

We have cloned a region of 124 kb of the human immunoglobulin lambda light chain locus on chromosome 22 encompassing seven V lambda and seven J-C lambda gene segments. No further C lambda gene segment was found in a region of 35 kb downstream of C lambda 7, which encodes the Ke+Oz- isot...read more

Mentioned in this Paper

Nucleic Acid Hybridization Procedure
Transcription, Genetic
Gene Deletion Abnormality
Immunoglobulin Isotypes
Human normal immunoglobulin
Genome Mapping
Immunoglobulin Light Chains
Partial Monosomy
Pseudogenes
Deletion Mutation
5
2

Similar Papers Found In These Feeds

Immune Tolerance

Immune tolerance happens when the immune system is not responsive to a substance or organism and does not elicit an immune response. This is a normal physiological response for some antigens, especially when detecting self from non-self. This has been a potential area of therapy for some disorders. Here is the latest research on immune tolerance.

Chromosomal Deletion

Chromosomal deletion includes the loss of a gene sequence of DNA. The location and the genes deleted determines the significance of this abnormality. There are many identified genetic disorders that are a result from chromosomal deletion including cri du chat and Prader-Willi syndrome. Discover the latest research on chromosomal deletions here.

Related Papers

The Journal of Experimental Medicine

Structure and expression of the human immunoglobulin lambda genes

The Journal of Experimental MedicineAugust 1, 1990
T J Vasicek, P Leder
European Journal of Immunology

Definition of the human immunoglobulin variable lambda (IGLV) gene subgroups

European Journal of ImmunologyJune 1, 1990
P ChuchanaM P Lefranc
Paper Details
References
  • References30
  • Citations54
12345...
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