PMID: 9171895Dec 1, 1996Paper

V lambda-light chain genes reconstitute immune responses to defined carbohydrate antigens or haptens by utilizing different VH genes

Molecular Immunology
A BotC Bona

Abstract

The contribution of the lambda-light chain to the development of peripheral B cell repertoire and generation of specific antibodies to haptens and polysaccharide antigens was studied in genetically manipulated kappa-deficient and lambda 2-transgenic mice. The results clearly demonstrate a non-stoichiometric VH gene family expression in the absence of k-light chain and suggest a non-stochastic pairing between VH and V lambda genes, expressed in the peripheral B cell repertoire. A shift in VH gene utilization in the case of VI lambda + antibodies was evident in response to beta 2-6 fructosan and TNP hapten. These observations demonstrate the availability of compensatory mechanisms in the absence of VK genes and are consistent with the hypothesis that VH gene family expression is controlled by genetic factors from inside the VH locus. Furthermore, genetic factors from outside the VH locus, namely restricted available light chain diversity, may lead to a shift in VH gene utilization in the peripheral B cell repertoire.

References

Oct 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·N Hozumi, S Tonegawa
Apr 1, 1991·European Journal of Immunology·P SanchezP A Cazenave
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A KaushikG Kelsoe
Aug 1, 1990·The Journal of Experimental Medicine·S L Kalled, P H Brodeur
May 1, 1989·The Journal of Experimental Medicine·A KaushikG Kelsoe
Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A M LawlerP J Gearhart
Jan 1, 1989·Immunogenetics·G KelsoeD H Schulze
Sep 1, 1987·European Journal of Immunology·T Blankenstein, U Krawinkel
Jul 1, 1988·The Journal of Experimental Medicine·G D YancopoulosF W Alt
Nov 20, 1987·Science·F W AltG D Yancopoulos
Nov 1, 1985·The Journal of Experimental Medicine·E A DzierzakA Bothwell
Apr 14, 1983·Nature·S Tonegawa
Jan 1, 1984·Annales d'immunologie·M FougereauC Tonnelle
Jun 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·B BlombergS Tonegawa
Sep 1, 1983·The Journal of Experimental Medicine·P Legrain, G Buttin
Sep 1, 1995·European Journal of Immunology·P BoudinotP Sanchez
Aug 1, 1993·Molecular Immunology·K N KasturiC A Bona
Feb 1, 1995·European Journal of Immunology·A KaushikJ C Jaton
Jan 1, 1993·Springer Seminars in Immunopathology·C Bona
Aug 1, 1993·European Journal of Immunology·V V Yurovsky, G Kelsoe
Apr 1, 1984·Immunology Today·R Dildrop

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