PMID: 9537651Apr 16, 1998Paper

v-src activation of the collagenase-1 (matrix metalloproteinase-1) promoter through PEA3 and STAT: requirement of extracellular signal-regulated kinases and inhibition by retinoic acid receptors

Molecular Carcinogenesis
M P VincentiC E Brinckerhoff

Abstract

Collagenase-1 (matrix metalloproteinase-1 (MMP-1)) degrades the extracellular matrix and enhances the invasive phenotype of tumor cells. v-src activated MMP-1 transcription through a series of elements in the proximal promoter, including the E2BP (nt -172), polyoma virus enhancer A3 (PEA3) (nt -94), activator protein-1 (AP-1) (nt -72), and signal transducer and activator of transcription (STAT) (nt -57) consensus sites. Of these sites, PEA3 and STAT contributed specifically to induction by v-src, whereas the remaining elements were also involved in induction by the phorbol ester phorbol myristate acetate (PMA). However, in contrast to MMP-1 induction by PMA, an AP-1 site located at nt -186 did not contribute to v-src induction. These results suggest divergence of the tyrosine kinase- and protein kinase C-dependent pathways with respect to MMP-1 transcription. v-src induced MMP-1 through mitogen-activated protein kinases, with extracellular signal-regulated kinases playing a larger role than c-jun N-terminal kinase. Retinoic acid, which inhibits the progression of certain cancers, repressed v-src-induced MMP-1 transcription. Constitutive expression of retinoic acid receptors (RARs) alpha or beta, but not gamma, or of retinoid X ...Continue Reading

References

Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·C A CartwrightW Eckhart
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·R H GrossC E Brinckerhoff
Nov 24, 1995·Science·Z XiaM E Greenberg
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·D K LuttrellT M Gilmer
Dec 1, 1994·Molecular and Cellular Biology·H K SlussR J Davis
Aug 1, 1994·Arthritis and Rheumatism·M P VincentiC E Brinckerhoff
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·J A FrostJ R Feramisco
Jul 1, 1993·Journal of Cellular Biochemistry·S H ChamberlainC E Brinckerhoff
Oct 1, 1995·Current Opinion in Cell Biology·H Birkedal-Hansen
Apr 1, 1996·Molecular and Cellular Biology·X CaoY H Tan
Jun 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T TeradaY Nakanuma
Jul 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·J D ChenR M Evans
Dec 1, 1995·Matrix Biology : Journal of the International Society for Matrix Biology·L A White, C E Brinckerhoff
Jan 31, 1997·The Journal of Biological Chemistry·G S CampbellC Carter-Su
Aug 8, 1997·Biochemical and Biophysical Research Communications·D J SchroenC E Brinckerhoff

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Citations

Aug 12, 2009·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Jeeyun LeeCheol Keun Park
Sep 6, 2005·Matrix Biology : Journal of the International Society for Matrix Biology·Teresa RobledoEduardo Pérez Salazar
Jul 23, 2004·Annals of Plastic Surgery·Howard LevinsonH Paul Ehrlich
Jul 27, 2004·Oncogene·Jan BrábekSteven K Hanks
Feb 3, 2006·Journal of Cellular Physiology·Lunyu KuoWen-Chun Hung

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