V3 vasopressin receptor and corticotropic phenotype in pituitary and nonpituitary tumors

Hormone Research
Y de KeyzerXavier Bertagna

Abstract

Pituitary corticotropic cells express a specific vasopressin receptor, called V1b or V3, through which vasopressin stimulates corticotropin secretion. We recently cloned a cDNA coding for this receptor and showed that it belongs to the G protein-coupled receptor family. V3 mRNA is readily detected by RT-PCR in normal human pituitaries and corticotropic pituitary adenomas but not in PRL or GH-secreting adenomas, thus demonstrating that, like POMC itself and the CRH receptor, V3 is a marker of the corticotropic phenotype. Nuclease protection experiments suggest that V3 is overexpressed in some corticotropic adenomas, and thus may play a role in tumor development by activating the phospholipase C-signalling pathway. In addition analysis of its expression in nonpituitary neuroendocrine tumors showed a striking association with carcinoids of the lung responsible for the ectopic ACTH syndrome.

Citations

Sep 1, 2005·Pituitary·Guillaume AssiéXavier Bertagna
May 24, 2003·Frontiers in Neuroendocrinology·Andy Levy, Stafford Lightman
Oct 19, 2002·Respiratory Physiology & Neurobiology·Prabha KcSerdia O Mack
Jul 30, 2010·European Journal of Endocrinology·T M BarberJ A H Wass
Dec 1, 2009·Best Practice & Research. Clinical Endocrinology & Metabolism·Xavier BertagnaJérôme Bertherat
May 16, 2006·Lancet·John Newell-PriceLynnette K Nieman
Dec 23, 1998·Endocrine Reviews·S L Asa, S Ezzat
Sep 29, 2006·Expert Review of Anticancer Therapy·Adam M SonabendMaciej S Lesniak
Feb 3, 2012·Physiological Reviews·Carolina Perez-CastroEduardo Arzt
Jan 23, 2008·Arquivos brasileiros de endocrinologia e metabologia·John Newell-Price, Ashley B Grossman
Jul 6, 2021·Frontiers in Endocrinology·Masaaki YamamotoHidenori Fukuoka

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