Vγ4 T Cells Inhibit the Pro-healing Functions of Dendritic Epidermal T Cells to Delay Skin Wound Closure Through IL-17A

Frontiers in Immunology
Yashu LiWeifeng He

Abstract

Dendritic epidermal T cells (DETCs) and dermal Vγ4 T cells engage in wound re-epithelialization and skin inflammation. However, it remains unknown whether a functional link between Vγ4 T cell pro-inflammation and DETC pro-healing exists to affect the outcome of skin wound closure. Here, we revealed that Vγ4 T cell-derived IL-17A inhibited IGF-1 production by DETCs to delay skin wound healing. Epidermal IL-1β and IL-23 were required for Vγ4 T cells to suppress IGF-1 production by DETCs after skin injury. Moreover, we clarified that IL-1β rather than IL-23 played a more important role in inhibiting IGF-1 production by DETCs in an NF-κB-dependent manner. Together, these findings suggested a mechanistic link between Vγ4 T cell-derived IL-17A, epidermal IL-1β/IL-23, DETC-derived IGF-1, and wound-healing responses in the skin.

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Citations

Aug 18, 2020·Cellular and Molecular Life Sciences : CMLS·Yingping XuQing-Sheng Mi
Aug 28, 2020·Immunological Reviews·Matthew A FischerKaren L Edelblum
Jun 22, 2018·Frontiers in Immunology·Michelle S CruzJulie Marie Jameson
Jun 4, 2020·Cellular Oncology (Dordrecht)·Łukasz ZadkaPiotr Dzięgiel
Jul 29, 2020·International Journal of Molecular Sciences·Elena GroppaSerena Zacchigna
Dec 13, 2019·Mediators of Inflammation·Yasmin HadianR Rivkah Isseroff
Jun 20, 2018·Frontiers in Immunology·Yashu LiWeifeng He
Dec 10, 2020·International Journal of Molecular Sciences·Luis D MunozJulie M Jameson
Mar 19, 2021·Frontiers in Immunology·Cong QiJingxia Zhao
Apr 1, 2021·Regenerative Medicine·Fan YangYong Li
May 4, 2021·Frontiers in Immunology·Joshua R CoxAmy E Saunders
Jun 25, 2021·International Immunopharmacology·Yao ZhangShogo Takashiba
Oct 6, 2021·International Reviews of Immunology·Natalija NovakBeatriz Cabanillas

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Methods Mentioned

BETA
PMA
FACS
confocal microscopy
protein assay
PCR

Software Mentioned

GraphPad Prism
FACS
FlowJo
SPSS19

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