Vaccinating for natural killer cell effector functions

Clinical & Translational Immunology
Helen R WagstaffeMartin R Goodier

Abstract

Vaccination has proved to be highly effective in reducing global mortality and eliminating infectious diseases. Building on this success will depend on the development of new and improved vaccines, new methods to determine efficacy and optimum dosing and new or refined adjuvant systems. NK cells are innate lymphoid cells that respond rapidly during primary infection but also have adaptive characteristics enabling them to integrate innate and acquired immune responses. NK cells are activated after vaccination against pathogens including influenza, yellow fever and tuberculosis, and their subsequent maturation, proliferation and effector function is dependent on myeloid accessory cell-derived cytokines such as IL-12, IL-18 and type I interferons. Activation of antigen-presenting cells by live attenuated or whole inactivated vaccines, or by the use of adjuvants, leads to enhanced and sustained NK cell activity, which in turn contributes to T cell recruitment and memory cell formation. This review explores the role of cytokine-activated NK cells as vaccine-induced effector cells and in recall responses and their potential contribution to vaccine and adjuvant development.

References

Jun 29, 1989·The New England Journal of Medicine·C A BironJ L Sullivan
May 30, 1998·Journal of Virology·J M MonteiroG Trinchieri
May 2, 2002·Clinical and Experimental Immunology·S BaizeE Mavoungou
Sep 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katerina Artavanis-Tsakonas, Eleanor M Riley
Jan 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Guido FerlazzoChristian Münz
Jul 14, 2004·The Journal of Experimental Medicine·Kelly L WarfieldSina Bavari
Aug 12, 2004·Blood·Mónica GumáMiguel López-Botet
Dec 16, 2004·The Journal of Clinical Investigation·Xiao-Song HeHarry B Greenberg
Apr 18, 2006·Nature Immunology·Jacqueline G O'LearyUlrich H von Andrian
Jul 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jacques RolandSylviane Pied
Mar 24, 2007·Nature Reviews. Immunology·Kirsty C Newman, Eleanor M Riley
Mar 27, 2007·Cellular Microbiology·Claudette L FullerSina Bavari
Nov 16, 2007·Clinical and Vaccine Immunology : CVI·Brian R LongDouglas F Nixon
Nov 21, 2007·The Journal of Experimental Medicine·Galit AlterMarcus Altfeld
Jan 4, 2008·The Journal of Infectious Diseases·Jakob MichaëlssonDouglas F Nixon
Nov 4, 2008·Trends in Microbiology·Mary CarringtonJeroen van Bergen
Nov 26, 2008·Nature Immunology·Troy D QuerecBali Pulendran
Jan 13, 2009·Nature·Joseph C SunLewis L Lanier
Feb 3, 2009·Proceedings of the National Academy of Sciences of the United States of America·Megan A CooperWayne M Yokoyama
Aug 4, 2009·Vaccine·Patrícia Cristina da Costa NevesRicardo Galler
Oct 20, 2009·Vaccine·Tamara K BerthoudStephen M Todryk
Apr 30, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amir HorowitzEleanor M Riley
Aug 4, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amir HorowitzEleanor M Riley
Dec 22, 2010·The Journal of Experimental Medicine·Niklas K BjörkströmHans-Gustaf Ljunggren
Aug 10, 2011·Proceedings of the National Academy of Sciences of the United States of America·Sandra Lopez-VergèsLewis L Lanier
Oct 4, 2011·Virus Research·J H C M KreijtzG F Rimmelzwaan
Apr 6, 2012·The New England Journal of Medicine·Barton F HaynesJerome H Kim
Apr 17, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amir HorowitzEleanor M Riley
May 25, 2012·PloS One·Katherine C VerbistKimberly D Klonowski
Aug 8, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Moyar Qing GeDavid Michael Kemeny
Sep 18, 2012·Blood·Rizwan RomeeTodd A Fehniger
Sep 19, 2012·Proceedings of the National Academy of Sciences of the United States of America·Johanneke KleinnijenhuisMihai G Netea
Jan 16, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sinthujan JegaskandaStephen J Kent
Jul 3, 2013·The Journal of Infectious Diseases·Sinthujan JegaskandaStephen J Kent
Jul 9, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Richard D AntrobusSarah C Gilbert

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Citations

Mar 29, 2019·Viruses·Christelle LangevinBertrand Collet
Aug 21, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Helen R WagstaffeMartin R Goodier
Sep 20, 2019·Malaria Journal·Kristina S BurrackSara E Hamilton
Nov 26, 2019·Immunological Reviews·Martin R GoodierEleanor M Riley
Mar 3, 2020·Frontiers in Immunology·Jason P MooneyEleanor M Riley
Aug 15, 2020·Frontiers in Immunology·Elisa NemesWillem A Hanekom
May 8, 2021·Clinical & Translational Immunology·Fernando Souza-Fonseca-Guimaraes
Jul 28, 2021·Trends in Pharmacological Sciences·Andrew CoxStephen N Waggoner

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