PMID: 11309150Apr 20, 2001Paper

Vaccination against Helicobacter pylori in non-human primate models and humans

Scandinavian Journal of Immunology
C K Lee

Abstract

Several vaccination studies have been performed in monkeys and humans testing the feasibility of prophylactic and therapeutic immunizations against Helicobacter pylori. The monkey studies showed that immune responses were induced by oral vaccination with the mucosal adjuvant LT (Escherichia coli heat-labile enterotoxin), parenteral administration with a cationic lipid adjuvant, and by mucosal priming followed by parenteral boosts. Both prophylactic and therapeutic activities were demonstrated in monkeys, providing a strong impetus for human vaccine trials. Preliminary studies in humans were undertaken in order to identify a tolerable dose of LT adjuvant or to test the effectiveness of mutant atoxic LT adjuvants. The results from these preliminary studies suggest that native LT causes diarrhoea at doses required for adjuvanticity while a mutant LT does not. In one study in which infected human subjects were vaccinated with orally administered urease antigen with native LT, there was a modest reduction in the level of H. pylori gastric colonization. A second clinical study employing H. pylori whole cell antigen and a mutant LT in infected subjects showed immune responses and although the subjects remained infected, the study was ...Continue Reading

References

Sep 1, 1996·Digestive Diseases and Sciences·C T StadtländerT P Monath
Jul 7, 1998·The Journal of Experimental Medicine·A G Farr, A Rudensky
Aug 26, 1998·Infection and Immunity·A DuboisT Monath
Oct 25, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·F W van GinkelJ R McGhee
Apr 20, 2001·Scandinavian Journal of Immunology·J G Nedrud

❮ Previous
Next ❯

Citations

Apr 20, 2001·Scandinavian Journal of Immunology·J G Nedrud
Oct 13, 2006·Current Opinion in Gastroenterology·R B Sartor
Jan 1, 1994·Journal of Gastroenterology and Hepatology·T S Gaginella
Jan 19, 2010·World Journal of Gastroenterology : WJG·Maritza LienlafAlejandro Venegas
Jan 5, 2012·World Journal of Gastroenterology : WJG·Simona CardaropoliTullia Todros
Nov 7, 2006·Helicobacter·Douglas EmancipatorSteven J Czinn
Dec 1, 2005·Scandinavian Journal of Immunology·Roland Jonsson
Mar 1, 2005·Vaccine·L C Freytag, J D Clements
Dec 4, 2003·Expert Opinion on Therapeutic Targets·Michael F Loughlin
Apr 20, 2007·FEMS Immunology and Medical Microbiology·Ann-Mari Svennerholm, Anna Lundgren
Sep 15, 2016·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Nabih Ibrahim ElkhoulyAyman A Shabana
Aug 29, 2002·Helicobacter·John G NedrudSteven J Czinn

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.