Vaccination against Lyme disease: Are we ready for it?

Human Vaccines & Immunotherapeutics
Patricia Kaaijk, Willem Luytjes

Abstract

Lyme disease is the most common tick-borne illness in the Northern hemisphere and is caused by spirochetes of the Borrelia burgdorferi sensu lato complex. A first sign of Borrelia infection is a circular skin rash, erythema migrans, but it can develop to more serious manifestations affecting skin, nervous system, joints, and/or heart. The marked increase in Lyme disease incidence over the past decades, the severity of the disease, and the associated high medical costs of, in particular, the persistent forms of Lyme disease requires adequate measures for control. Vaccination would be the most effective intervention for prevention, but at present no vaccine is available. In the 1990s, 2 vaccines against Lyme disease based on the OspA protein from the predominant Borrelia species of the US showed to be safe and effective in clinical phase III studies. However, failed public acceptance led to the demise of these monovalent OspA-based vaccines. Nowadays, public seem to be more aware of the serious health problems that Lyme disease can cause and seem more ready for the use of a broadly protective vaccine. This article discusses several aspects that should be considered to enable the development and implementation of a vaccine to prev...Continue Reading

References

Jun 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·E FikrigR A Flavell
Jun 18, 1982·Science·W BurgdorferJ P Davis
Jan 1, 1996·The Journal of Experimental Medicine·A M de SilvaE Fikrig
Jul 14, 2001·The New England Journal of Medicine·R B NadelmanUNKNOWN Tick Bite Study Group
Sep 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Antti AlitaloSeppo Meri
Feb 26, 2005·Infection and Immunity·Clay L Gipson, Aravinda M de Silva
Nov 5, 2005·Applied and Environmental Microbiology·Carolin Rauter, Thomas Hartung
Aug 9, 2006·Epidemiology and Infection·L E Nigrovic, K M Thompson
Jun 21, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Paul G Auwaerter
Apr 4, 2009·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Kathryn L JonesAllen C Steere
Apr 16, 2010·Clinical and Vaccine Immunology : CVI·Peter D BurbeloAdriana Marques
Jul 3, 2010·Trends in Parasitology·T J SchuijtE Fikrig
Jan 19, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Angela K ShenCharles B Beard
Jan 1, 2006·Environmental Health and Preventive Medicine·Derek R Smith, Rui-Sheng Wang
Jun 4, 2011·FEMS Immunology and Medical Microbiology·Gunthard StübsNicolas W J Schröder
Sep 10, 2011·Lancet·Gerold StanekFranc Strle
Jun 22, 2012·Clinical and Vaccine Immunology : CVI·Monica E EmbersMario T Philipp
Apr 18, 2013·PloS One·Artem S Rogovskyy, Troy Bankhead
Aug 24, 2013·Frontiers in Cellular and Infection Microbiology·Mária Kazimírová, Iveta Štibrániová
Feb 25, 2014·Parasites & Vectors·Hein SprongJoppe W R Hovius
Jul 8, 2014·Nature Medicine·Cassandra Willyard
Dec 3, 2014·Ticks and Tick-borne Diseases·Agnetha HofhuisWilfrid van Pelt
Feb 5, 2015·PloS One·Emily R AdrionJonathan P Weiner

❮ Previous
Next ❯

Citations

Aug 17, 2018·Molecular Omics·Elena BencurovaThomas Dandekar
May 6, 2019·International Journal of Environmental Research and Public Health·Mario Levesque, Matthew Klohn

❮ Previous
Next ❯

Software Mentioned

ImuLyme

Related Concepts

Related Feeds

Babesiosis

Babesiosis is caused by parasites of the genus babesia, which are transmitted in nature by the bite of an infected tick. Discover the latest research on babesiosis here.