Vaccination against tick-borne encephalitis virus tests specific IgG production ability in patients under immunoglobulin substitution therapy

Vaccine
Markus G SeidelElisabeth Förster-Waldl

Abstract

To assess B-cell function in patients under immunoglobulin (IgG)-replacement therapy, the non-licensed artificial bacteriophage (ΦX174)-neo-antigen may be used despite limited availability and experience. Active immunization against tick-borne encephalitis (TBE) is performed in few European countries. To test the feasibility of using licensed TBE vaccination as (neo-)antigen to determine residual or restored B-cell function in patients under regular IgG substitution, TBE-IgG levels were analyzed in 18 patients with ≥ 1-2 years of regular intravenous or subcutaneous IgG substitution and in pharmaceutical IgG-preparations (n=21 batches, 10 products). Six individuals were boosted against TBE. Although TBE-specific IgG was detectable in concentrates (281-57,100 VieU/0.5 μL), levels were only borderline in patient sera (n=31, 18 individuals; median 132 VieU; positive >155). Thus, TBE vaccination may be used to test B-cell function under IgG replacement therapy because IgG substitution appears insufficient to yield protective TBE-specific antibody levels in children.

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Citations

Aug 31, 2013·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Mark Ballow
Jan 1, 2013·The Journal of Allergy and Clinical Immunology·Markus G SeidelElisabeth Förster-Waldl
Jan 1, 2013·The Journal of Allergy and Clinical Immunology·Jordan S Orange, Rohit Katial
Aug 1, 2012·The Journal of Allergy and Clinical Immunology·Roshini S Abraham
Mar 2, 2012·Clinical and Vaccine Immunology : CVI·Philip O RabelThomas R Kreil

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