Vaccination as a novel approach for treating depressive behavior

Biological Psychiatry
G M LewitusMichal Schwartz

Abstract

Depressive behavior in animals is often associated with reduced levels of brain-derived neurotrophic factor (BDNF) and impaired neurogenesis in the hippocampus. Recent studies showed that T cells recognizing central nervous system (CNS)-specific antigens can regulate adult hippocampal neurogenesis and expression of BDNF. On the basis of these findings, we hypothesized that controlling CNS specific immune activity by immunization with a myelin-related peptide may have an antidepressant effect. We investigated the impact of immunization with a CNS related peptide, on the behavioral and cellular outcomes of chronic mild stress (CMS; an animal model for depression) in rats. Immunization with a weak agonist of a myelin-derived peptide ameliorated depressive behavior such as anhedonia (measured by sucrose preference), induced by CMS in rats. The behavioral outcome was accompanied by restoration of hippocampal BDNF levels and neurogenesis. The results of this study introduce a novel approach of immunization with CNS-related antigens as a therapeutic means for fighting depression. Vaccination, as an antidepressant therapy, may invoke several molecular and cellular pathways that are known to be regulated by antidepressant drugs. Therefo...Continue Reading

References

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Citations

Aug 21, 2010·Immunologic Research·K Grovit-Ferbas, M E Harris-White
Sep 16, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ebrahim HaroonAndrew H Miller
Jun 10, 2010·Nature Reviews. Neurology·Michal Schwartz, Ravid Shechter
Oct 16, 2012·Current Pharmaceutical Design·Jennifer P Chou, Rita B Effros
Feb 15, 2014·Brain, Behavior, and Immunity·Sarah M ClarkLeonardo H Tonelli
Dec 4, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Rita HaapakoskiMika Kivimäki
Apr 18, 2012·Drug Discovery Today·Graham A W RookChristopher A Lowry
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Apr 17, 2010·Clinical Psychology Review·Dmitry M DavydovIsabelle Chaudieu
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Oct 13, 2009·Brain, Behavior, and Immunity·Andrew H Miller
Jun 13, 2009·Trends in Neurosciences·Noga Ron-Harel, Michal Schwartz
May 16, 2009·Frontiers in Neuroendocrinology·Francesca Cirulli, Enrico Alleva
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Sep 29, 2009·Journal of Neurochemistry·Maya Koronyo-HamaouiMichal Schwartz
Aug 21, 2012·Nature Reviews. Immunology·Jonathan KipnisNoël C Derecki

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