Vaccination of cows with a K99 extract to protect newborn calves against experimental enterotoxic colibacillosis.

Infection and Immunity
B Nagy

Abstract

Pregnant cows and heifers were vaccinated with a crude K99 extract prepared from an Escherichia coli K-12, K99 strain. A similar group, injected with an extract prepared from the K-12 parent strain, served as a control. Eleven calves were born to both groups and challenged orally with a mean of 1.6 x 10(11) bacteria of enterotoxic E. coli B41 (O101:K99+, ST+) at the time of first colostrum uptake (1 to 7 h after birth). As a result of challenge, no death occurred in the vaccine group, but four calves died in the control group. Six calves in the vaccine group and all calves in the control group developed diarrhea. Colostral anti-O101 titers were very similar in both groups. Anti-K99 titers of colostral samples from the vaccinated dams were, however, significantly higher as compared to those of the controls. It is suggested that colostral antibodies, raised against the crude K99 extract vaccine, exerted a protective effect on newborn calves against the challenge enterotoxigenic E. coli O101:K99+, Ent+ strain.

References

Mar 1, 1976·Infection and Immunity·S FalkowL D Rollins

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Citations

Dec 1, 1990·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·B NagyB Morein
Oct 1, 1984·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·P A BachmannA Mayr
Jan 1, 1985·Journal of Dairy Science·S D Acres
Mar 27, 1999·Molecular Microbiology·H Sakellaris, J R Scott
Aug 1, 1985·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·M Awad-Masalmeh, H Willinger
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·H SakellarisJ R Scott
Oct 22, 2005·Infection and Immunity·Miguel A AscónDavid W Pascual
Oct 3, 2008·Transgenic Research·Ganesan SunilkumarKeerti S Rathore
Oct 3, 2012·Infection and Immunity·Xiaogang Wang, Philip R Hardwidge
Jun 1, 1982·Microbiological Reviews·W Gaastra, F K de Graaf
Jan 1, 1981·Pharmacology & Therapeutics·R N Greenberg, R L Guerrant
Oct 14, 2016·EcoSal Plus·J Daniel DubreuilDieter M Schifferli
Jun 1, 1983·Infection and Immunity·H MettK Vosbeck
Jan 1, 1991·Archives of Oral Biology·S J FillerJ R McGhee

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