PMID: 9550214Apr 29, 1998Paper

Vaccination of langur monkeys (Presbytis entellus) against Leishmania donovani with autoclaved L. major plus BCG

Parasitology
A DubeJ C Katiyar

Abstract

The protective potential of killed Leishmania major (ALM) along with BCG was evaluated against L. donovani in Indian langur monkeys in single and triple dose schedules. A delayed protection was observed in monkeys after a single dose schedule of ALM (3 mg)+BCG (3 mg) given intradermally 2 months before intravenous challenge with L. donovani. Triple dose schedule each of 1 mg ALM + 1 mg BCG was more effective. The status remained unchanged until the end of the experiment (approximately 8 months). The study indicates that a combination of ALM + BCG may be a good candidate vaccine for exploiting against human Kala-azar.

Citations

Jan 17, 2014·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Tejinder KaurSukhbir Kaur
Feb 4, 2006·Transactions of the Royal Society of Tropical Medicine and Hygiene·R PorrozziG Grimaldi
Jun 29, 1999·Clinics in Dermatology·C L Jaffe
Apr 12, 2001·Medical and Veterinary Entomology·R J ProbstE D Rowton
Jul 22, 2005·PLoS Medicine·Asrat HailuMonique Wasunna
Oct 13, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Swati BhowmickNahid Ali
Feb 21, 2014·Revista Do Instituto De Medicina Tropical De São Paulo·Elsy Nalleli Loría-Cervera, Fernando José Andrade-Narváez
Jun 23, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mukesh SamantAnuradha Dube
Nov 11, 2019·Drug Discovery Today·Maria E SheeanVioleta Stoyanova-Beninska

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