PMID: 8588333Nov 1, 1995Paper

Vaccination of racing greyhounds: effects on humoral and cellular immunity

Veterinary Immunology and Immunopathology
G L McMillenF R Jordan

Abstract

Greyhound kennel owners frequently employ multiple vaccination schedules in an attempt to reduce financial losses incurred as a result of infectious diseases. In order to determine the effects of multiple vaccination schedules on the immune system of racing greyhounds, three litters of greyhound pups raised in laboratory conditions were divided into two groups and subjected to either a maximum or a minimum vaccination schedule. Blood samples were collected biweekly for 6 months beginning at 2 weeks of age and analyzed to establish 'baseline' values for the lymphatic system of greyhounds. Lymphocyte transformation, total and differential leukocyte counts, and flow cytometry were used to evaluate cellular immunity. Humoral immunity was evaluated using serum neutralization and hemagglutination inhibition tests. Proliferation of peripheral blood lymphocytes in response to the mitogen concanavalin A (Con A) was higher for the maximum vaccination groups. The frequency distribution of circulating CD4 and IgG labeled lymphocytes was higher in the minimum vaccination groups. A significant treatment by time interaction in CD4, IgG, and IgM labeled cells was observed, This interaction, however, was not significant at any point in time for...Continue Reading

References

Aug 1, 1992·Veterinary Immunology and Immunopathology·D H Gebhard, P B Carter
Jan 1, 1992·Life Sciences·M H HuangS R Wang
Jul 1, 1991·Veterinary Immunology and Immunopathology·G A DeanE A Hoover
Mar 1, 1986·Veterinary Immunology and Immunopathology·S Krakowka, S S Ringler

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Citations

Aug 12, 2003·Veterinary Immunology and Immunopathology·Alois StrasserHans Niedermüller
Jun 15, 2007·Journal of Comparative Pathology·M J Day
Mar 6, 2007·The Veterinary Clinics of North America. Small Animal Practice·Anne C Avery, Paul R Avery
Jul 12, 2001·The Veterinary Clinics of North America. Small Animal Practice·E K Meyer
May 17, 2006·Veterinary Microbiology·M J Day

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