Vaccination of rhesus macaques with recombinant Mycobacterium bovis bacillus Calmette-Guérin Env V3 elicits neutralizing antibody-mediated protection against simian-human immunodeficiency virus with a homologous but not a heterologous V3 motif

Journal of Virology
Kenji SomeyaMitsuo Honda

Abstract

Although the correlates of vaccine-induced protection against human immunodeficiency virus type 1 (HIV-1) are not fully known, it is presumed that neutralizing antibodies (NAb) play a role in controlling virus infection. In this study, we examined immune responses elicited in rhesus macaques following vaccination with recombinant Mycobacterium bovis bacillus Calmette-Guérin expressing an HIV-1 Env V3 antigen (rBCG Env V3). We also determined the effect of vaccination on protection against challenge with either a simian-human immunodeficiency virus (SHIV-MN) or a highly pathogenic SHIV strain (SHIV-89.6PD). Immunization with rBCG Env V3 elicited significant levels of NAb for the 24 weeks tested that were predominantly HIV-1 type specific. Sera from the immunized macaques neutralized primary HIV-1 isolates in vitro, including HIV-1BZ167/X4, HIV-1SF2/X4, HIV-1CI2/X4, and, to a lesser extent, HIV-1MNp/X4, all of which contain a V3 sequence homologous to that of rBCG Env V3. In contrast, neutralization was not observed against HIV-1SF33/X4, which has a heterologous V3 sequence, nor was it found against primary HIV-1 R5 isolates from either clade A or B. Furthermore, the viral load in the vaccinated macaques was significantly reduced...Continue Reading

References

Jun 6, 1991·Nature·C K StoverG F Hatfull
Mar 1, 1989·Reviews of Infectious Diseases·B R Bloom
Apr 1, 1994·Science·J B GhiaraI A Wilson
Jan 15, 1996·FEMS Microbiology Letters·S MatsumotoT Yamada
Jun 1, 1996·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·Y LuB Roberts
Feb 1, 1996·Annals of Medicine·B F HaynesJ B Weinberg
Aug 26, 1998·AIDS Research and Human Retroviruses·P T KitsutaniW Sugiura
Feb 5, 2000·AIDS Research and Human Retroviruses·L A FalkS Yamazaki
Apr 3, 2001·Science·D Paydarfar, W J Schwartz
Nov 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·T HiroiH Kiyono
Jan 5, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Martin O C OtaArnaud Marchant
Jan 18, 2002·Nature·Jeffrey D Lifson, Malcolm A Martin
Feb 28, 2002·Annual Review of Immunology·Norman L LetvinDavid C Montefiori
Mar 5, 2002·Nature Medicine·Mark B Feinberg, John P Moore
May 2, 2002·Vaccine·Gary J Nabel
May 11, 2002·Nature Reviews. Immunology·Harriet L Robinson
Jul 2, 2002·Science·Gary NabelJose Esparza
Jul 18, 2002·IUBMB Life·Robin A Weiss

❮ Previous
Next ❯

Citations

Nov 7, 2006·AIDS·Josef Vlasak, Ruth M Ruprecht
May 10, 2005·Immunology and Cell Biology·Diane E WebsterSteve L Wesselingh
Sep 2, 2009·Vaccine·Reginaldo G BastosOdir A Dellagostin
Jun 14, 2008·Journal of Medical Virology·Koushi YamaguchiMitsuo Honda
Dec 23, 2006·Expert Review of Vaccines·Joan JosephJosep Maria Gatell
Nov 5, 2008·Expert Review of Vaccines·Sean P McBurney, Ted M Ross
May 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Donald N ForthalTran Phan
Jan 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kenji SomeyaMitsuo Honda
Jul 6, 2021·Expert Review of Vaccines·Lazaro M Marques-NetoLuciana C C Leite

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.