Vaccination of sheep against Fasciola hepatica with homologous fatty acid binding proteins

Veterinary Parasitology
V RamajoA Muro

Abstract

The current study was designed to test the immunoprophylactic properties of native (nFh12) and recombinant (rFh15) antigens from Fasciola hepatica in sheep subsequently infected with the fluke. Thirty lambs were divided into six groups according to various patterns of immunisation and times of infection and necropsy. The antigens were emulsified in Freund's adjuvant. Levels of specific anti-nFh12 and anti-rFh15 antibodies rose rapidly by 2 weeks after the first immunisation and were always significantly higher in immunised-infected sheep than in control-infected sheep. On completion of the trial there was no difference in fluke burden between groups vaccinated with either of the antigens and non-immunised controls. However, worm size and faecal egg counts were significantly diminished in the sheep vaccinated with either of the antigens, suggesting an anti-fecundity effect. This is the first report of experimental vaccination of sheep against F. hepatica with purified native and recombinant antigens related to fatty acid binding proteins.

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Citations

Jun 30, 2005·Parasitology Research·P Azhahia NambiMohini Saini
Jun 2, 2006·Parasitology Research·C González-LanzaB Revilla-Nuín
Feb 12, 2014·Pakistan Journal of Biological Sciences : PJBS·H Abou-ElhakamA El Amir
Jan 21, 2006·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Adriana Esteves, Ricardo Ehrlich
Sep 8, 2015·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Raafat Mohamed ShaapanEman Hussein Abdel-Rahman
Dec 9, 2014·TheScientificWorldJournal·Sultan AyazSadaf Niaz
Sep 10, 2014·International Journal for Parasitology·Hayley ToetTerry W Spithill
Apr 24, 2012·Veterinary Parasitology·F A Rojo-VázquezM Martínez-Valladares
Nov 1, 2016·Journal of the South African Veterinary Association·Ishmael F JajaVoster Muchenje
Sep 11, 2004·The Journal of Parasitology·Ana M Espino, George V Hillyer
Sep 13, 2005·Journal of Helminthology·G V Hillyer
Sep 8, 2004·Veterinary Parasitology·O K RainaS C Yadav

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