Vaccination Strategies against Malaria: novel carrier(s) more than a tour de force

Journal of Controlled Release : Official Journal of the Controlled Release Society
Rajeev K TyagiTejram Sahu

Abstract

The introduction of vaccine technology has facilitated an unprecedented multi-antigen approach to develop an effective vaccine against complex systemic inflammatory pathogens such as Plasmodium spp. that cause severe malaria. The capacity of multi subunit DNA vaccine encoding different stage Plasmodium antigens to induce CD8(+) cytotoxic T lymphocytes and interferon-γ responses in mice, monkeys and humans has been observed. Moreover, genetic vaccination may be capable of eliciting both cell mediated and humoral immune responses. The cytotoxic T cell responses are categorically needed against intracellular hepatic stage and humoral response with antibodies targeted against antigens from all stages of malaria parasite life cycle. Therefore, the key to success for any DNA based vaccine is to design a vector able to serve as a safe and efficient delivery system. This has encouraged the development of non-viral DNA-mediated gene transfer techniques such as liposome, virosomes, microsphere and nanoparticles. Efficient and relatively safe DNA transfection using lipoplexes makes them an appealing alternative to be explored for gene delivery. Also, liposome-entrapped DNA has been shown to enhance the potency of DNA vaccines, possibly by...Continue Reading

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Citations

Jun 10, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Neeraj K GargRajeev K Tyagi
Oct 5, 2013·Expert Opinion on Drug Discovery·Jana HeldBenjamin Mordmüller
Jun 19, 2013·Immunological Reviews·Christina C ChangSharon R Lewin
Nov 28, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Monika HåkerudPål Johansen
Oct 20, 2018·Frontiers in Immunology·Rashmirekha PatiAvinash Sonawane
Feb 18, 2020·Frontiers in Pharmacology·Qingjia ChiHuaping Liang

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