PMID: 11319774Apr 25, 2001Paper

Vaccination with a CDR2 BV6S2/6S5 peptide in adjuvant induces peptide-specific T-cell responses in patients with multiple sclerosis

Journal of Neuroscience Research
E E MorganD J Carlo

Abstract

Earlier studies from several groups including ours have documented that patients with multiple sclerosis (MS) have over-expression of activated T-cells from specific TCR V beta families, including BV6S2/S5 (Kotzin et al. [1991] Proc. Natl. Acad. Sci. USA 88:9161--9165; Gold et al. [1997] J. Neuroimmunol. 76:29--38). It has also been established in the rat EAE model that peptide vaccines to the over-expressed V beta 8.2 TCR can prevent MBP induced disease (Vandenbark et al. [1989] Nature 341:541--544). In the current clinical study, 10 patients were vaccinated with 300 microg of BV6S2/6S5 peptide emulsified in incomplete Freund's adjuvant (IFA) and monitored for safety and immunogenicity in a 48-week multicenter, open-label trial. The peptide vaccine was well tolerated and no serious adverse events were observed. Vaccinations induced cell-mediated immunity to the immunizing peptide in eight of 10 patients as demonstrated by lymphocyte proliferation assay (LPA) and delayed-type hypersensitivity (DTH) skin test responses. In summary, these results demonstrate that immunization with TCR BV6S2/6S5 peptide vaccine in MS patients is safe and immunogenic, and supports a larger double-blind placebo controlled trial to determine the clin...Continue Reading

References

Nov 21, 1978·Biochimica Et Biophysica Acta·K V Shooter, R K Merrifield
Oct 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·B L KotzinA A Vandenbark

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Citations

Jan 22, 2005·Annual Review of Medicine·Jingwu Zhang, George Hutton
Aug 13, 2004·Proceedings of the National Academy of Sciences of the United States of America·Reinhard Hohlfeld, Hartmut Wekerle
Dec 2, 2005·International Reviews of Immunology·Mireia Sospedra, Roland Martin
Nov 3, 2005·Expert Opinion on Emerging Drugs·Rachel FarrellGavin Giovannoni
Nov 1, 2008·Nature Reviews. Drug Discovery·Rocio S Lopez-Diego, Howard L Weiner
Aug 25, 2005·Expert Review of Vaccines·Sylvia Cohen-Kaminsky, Florence Jambou
Sep 1, 2005·Expert Review of Clinical Immunology·Mark T MuirMichael K Racke
Jan 5, 2006·Autoimmunity·Erica Lee, Animesh A Sinha
Nov 13, 2003·Expert Opinion on Emerging Drugs·Emmanuelle Waubant
Oct 1, 2005·Multiple Sclerosis : Clinical and Laboratory Research·D N BourdetteA A Vandenbark

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