Vaccination with a chaperone complex based on PSCA and GRP170 adjuvant enhances the CTL response and inhibits the tumor growth in mice

Vaccine
Wenqian HuoQiansheng Li

Abstract

Increasing knowledge demonstrate that prostate stem cell antigen (PSCA) is a promising candidate for immunotherapy of advanced prostate cancer. However, tumor escape with down-regulation of target antigens may limit the susceptibility of tumor cells to the immune attack. Concomitant generation of T-cell responses against several immunodominant antigens may circumvent this potential drawback. In this study, we prepared the chaperone complex vaccine based on PSCA and GRP170, and utilized it to immunize the C57BL/6 mice. In addition, the T-cell response was monitored with ELISPOT and (51)Cr-release assays, and the tumor growth and the life span of tumor-bearing mice were assessed. The results demonstrated the chaperone complex based on PSCA and GRP170 could enhance the T-cell mediate immune responses, which significantly inhibited the tumor growth and prolonged the life span of tumor-bearing mice. In conclusion, our findings supported the strategy of chaperone complex, based on PSCA and GRP170, could be an effective treatment for prostate cancer therapy.

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Citations

Mar 15, 2016·Frontiers in Immunology·Daming ZuoXiang-Yang Wang
Jul 9, 2013·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Xiang-Yang Wang, John R Subjeck
Feb 24, 2015·Journal of Molecular Biology·Julia BehnkeLinda M Hendershot
Jan 30, 2015·Frontiers in Oncology·Hongxia WangXiang-Yang Wang
May 17, 2014·Frontiers in Immunology·Harm WestdorpI Jolanda M de Vries
Jan 30, 2018·Current Medicinal Chemistry·Alexey V BaldinLyudmila V Savvateeva

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