Vaccination with an Epitope Peptide of IZUMO1 to Induce Contraception in Female Mice

American Journal of Reproductive Immunology : AJRI
Feng XueChen Xu

Abstract

The development of a new and suitable contraceptive methods, as well as in-depth and systematic research into underlying contraceptive mechanisms, is crucial. IZUMO1 plays an important role in the fusion of the sperm and ovum during fertilization. Izumo(-/-) mice are infertile. Therefore, IZUMO1 may be a potential target for the development of a contraceptive vaccine. Linear B-cell epitopes (BCE) were identified in IZUMO using biosynthetic peptides and used to immunize female mice. Five IZUMO BCE were identified: DLVLDCL177-183, YSFYRV196-201 (named BCE-2), YLT217-219, SMVGPED221-227, and DAGNY228-232. Active immunization with the BCE-2 vaccine sharply decreased the fertility rate in female mice in a safe and reversible manner. In vitro fertilization showed that the BCE-2 vaccine interferes with and blocks the fusion of the sperm and the ovum. B-cell epitopes-2 may be a new candidate for the development of contraceptive vaccine due to its effectiveness, safety, and reversibility.

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Citations

Oct 23, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Geraldine BossardPhilippe Holzmuller
Oct 2, 2019·International Journal of Molecular Sciences·Takako SaitoNaokazu Inoue
Oct 6, 2020·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Jolie A Carlisle, Willie J Swanson

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