Vaccination with fixed feline immunodeficiency virus (FIV) infected cells: protection, breakthrough and specificity of response

Vaccine
S A BishopD A Harbour

Abstract

Infection of cats with feline immunodeficiency virus (FIV), a naturally occurring lentivirus infection of cats which causes an AIDS-like disease, has generated considerable interest as an animal model for HIV vaccination. This paper reports on experiments performed to examine the potential of a fixed infected cell vaccine to confer protection against intraperitoneal challenge with cell-free FIV. The cell vaccine was highly immunogenic and elicited antibody responses to virus core antigen, p24, high virus neutralizing (VN) antibody titres, and antibodies which recognized cellular components of the vaccine. Whilst protection, assessed by the inability to detect infectious virus by virus isolation or polymerase chain reaction, against homologous but not heterologous FIV isolates was apparent up to week 12 post-challenge, when cats were monitored longer up to week 50 post-challenge a breakthrough in vaccine protection against homologous virus was observed. Protection could not be correlated with levels of antibody to p24 or VN antibody titres. In contrast with simian immunodeficiency virus vaccine studies in macaques there was no clear evidence that antibodies recognizing cellular components of the vaccine, including MHC class I an...Continue Reading

References

Dec 1, 1992·Veterinary Immunology and Immunopathology·M J HosieO Jarrett
Sep 1, 1992·AIDS Research and Human Retroviruses·A J LangloisD P Bolognesi
Nov 1, 1991·AIDS Research and Human Retroviruses·J K YamamotoM B Gardner
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Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R C DesrosiersM D Daniel
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Dec 1, 1994·The Journal of General Virology·R OsborneO Jarrett
Jan 1, 1994·The British Veterinary Journal·M J Hosie
Jan 1, 1993·AIDS Research and Human Retroviruses·M P CranageP Kitchin

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Citations

Dec 5, 1998·Veterinary Immunology and Immunopathology·J A KarlasA D Osterhaus
May 13, 2008·Veterinary Immunology and Immunopathology·F Reggeti, D Bienzle
Nov 15, 2008·Journal of Cellular Biochemistry·S MontagnaroU Pagnini

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