Vaccination with polysaccharide-conjugate-vaccines in adult patients with specific antibody deficiency

Vaccine
Anna ShrimptonLoems Ziegler-Heitbrock

Abstract

We report on a cohort of seven adult patients with specific antibody deficiency, defined by failure to respond to 23-valent Streptococcus pneumoniae vaccine while being able to respond to tetanus toxoid. Antibodies to Hemophilus influenzae (HiB) polysaccharides either pre-existed or were readily induced by a single vaccination with the HiB-tetanus toxoid conjugate. By contrast a single vaccination with the S. pneumoniae-diphtheria conjugate failed to induce a response to any of the seven serotypes in any of the seven patients. After a second vaccination in six patients, two patients continued to show no response but four showed a 3- to 45-fold response with development of >1 microg/ml of IgG to 2-4 of the serotypes, respectively. The data show that conjugate vaccines can enforce a response in adult patients with selective antibody deficiency but, dependent on the type of polysaccharide-conjugate, repeated immunisation and monitoring of the response is required.

Citations

Dec 7, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lorry G Rubin Infectious Diseases Society of America
Sep 5, 2006·Journal of Clinical Pathology·Paul BalmerRay Borrow
Jun 18, 2015·Expert Review of Vaccines·Mark A FletcherNathalie Dartois
May 13, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Partha P Majumder
May 20, 2014·Vaccine·Nicola Principi, Susanna Esposito

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