Vaccine adjuvant systems: enhancing the efficacy of sub-unit protein antigens

International Journal of Pharmaceutics
Yvonne PerrieVincent W Bramwell

Abstract

Vaccination remains a key tool in the protection and eradication of diseases. However, the development of new safe and effective vaccines is not easy. Various live organism based vaccines currently licensed, exhibit high efficacy; however, this benefit is associated with risk, due to the adverse reactions found with these vaccines. Therefore, in the development of vaccines, the associated risk-benefit issues need to be addressed. Sub-unit proteins offer a much safer alternative; however, their efficacy is low. The use of adjuvanted systems have proven to enhance the immunogenicity of these sub-unit vaccines through protection (i.e. preventing degradation of the antigen in vivo) and enhanced targeting of these antigens to professional antigen-presenting cells. Understanding of the immunological implications of the related disease will enable validation for the design and development of potential adjuvant systems. Novel adjuvant research involves the combination of both pharmaceutical analysis accompanied by detailed immunological investigations, whereby, pharmaceutically designed adjuvants are driven by an increased understanding of mechanisms of adjuvant activity, largely facilitated by description of highly specific innate imm...Continue Reading

References

Jan 1, 1976·Biochemical Society Transactions·C D Black, G Gregoriadis
Dec 15, 1979·International Journal of Cancer. Journal International Du Cancer·M V PimmE Lederer
Nov 9, 1992·Biochimica Et Biophysica Acta·H FarhoodL Huang
Dec 1, 1993·The Journal of Experimental Medicine·J L FlynnB R Bloom
Sep 19, 1997·The New England Journal of Medicine·M Angell
Nov 14, 1997·Lancet·G J Nossal
Feb 12, 1998·The Journal of Clinical Investigation·V KaranikasI F McKenzie
Nov 4, 1998·Seminars in Immunology·R Medzhitov, C A Janeway
Jan 20, 2000·Infection and Immunity·L BrandtP Andersen
Jun 17, 2000·Science·S Blume, I Geesink
Jul 19, 2000·Current Opinion in Immunology·V E Schijns
May 19, 2001·International Immunopharmacology·O Takeuchi, S Akira
Aug 20, 2002·Vaccine·Norman W BaylorPaul Richman
Aug 20, 2002·Vaccine·C J Clements, E Griffiths
Dec 13, 2002·Vaccine·Robert Mischler, Ian C Metcalfe
Mar 29, 2003·Critical Reviews in Therapeutic Drug Carrier Systems·H Oya Alpar, Vincent W Bramwell
Sep 19, 2003·Trends in Microbiology·Rob Noad, Polly Roy
Apr 9, 2004·The Pediatric Infectious Disease Journal·Güler KanraNicola Principi
Jun 19, 2004·Journal of Drug Targeting·Y PerrieA Vangala
Jul 23, 2004·Expert Opinion on Biological Therapy·Jory R BaldridgeDavid Persing
Aug 18, 2004·Microbes and Infection·Valerie QuesniauxBernhard Ryffel
Oct 19, 2004·Trends in Microbiology·Mihai G NeteaBart-Jan Kullberg
Oct 19, 2004·International Journal of Pharmaceutics·A R MohammedY Perrie
Nov 20, 2004·Immunology and Cell Biology·S A MoschosH O Alpar
Nov 20, 2004·Immunology and Cell Biology·Circe Mesa, Luis E Fernández
Nov 24, 2004·Microbes and Infection·Takashi KobayashiYongwon Choi
Nov 25, 2004·Advanced Drug Delivery Reviews·Tazio StorniPål Johansen
Feb 16, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Patrick H DemanaThomas Rades
Apr 7, 2005·Nature Medicine·Stanley A Plotkin
May 3, 2005·Critical Reviews in Therapeutic Drug Carrier Systems·Vincent W Bramwell, Yvonne Perrie

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Citations

Feb 20, 2013·Biologie aujourd'hui·Jose Vicente Gonzalez-AramundizMaría José Alonso
Jul 16, 2010·Clinical and Vaccine Immunology : CVI·I TamayoC Gamazo
Jul 21, 2011·Journal of Drug Delivery·Aiala SalvadorJosé Luis Pedraz
Apr 25, 2013·PloS One·Sara VicenteMaria J Alonso
Apr 25, 2012·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·O PérezV E J C Schijns
Sep 6, 2012·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·I P Nascimento, L C C Leite
May 14, 2010·International Journal of Nanomedicine·Ana Maria Carmona-Ribeiro
Jul 20, 2010·Immunotherapy·Alexander Link, Martin F Bachmann
Jul 25, 2012·Therapeutic Delivery·Regina Scherliess
Aug 6, 2014·International Journal of Pharmaceutics·S A Moreno-MendietaR Rodríguez-Sanoja
May 17, 2014·Current Opinion in Biotechnology·Joseph A RosenthalMatthew P DeLisa
Mar 29, 2014·Nanomedicine·Sara VicenteMaria J Alonso
Sep 10, 2015·Vaccines·Shiladitya DasSarma, Priya DasSarma
Jun 23, 2009·Expert Review of Vaccines·H Ciğdem ArcaSevda Senel
Oct 26, 2011·Journal of Drug Targeting·Carla G MoutinhoVictor M Balcão
Apr 20, 2012·Expert Opinion on Drug Delivery·Sevda ŞenelIndiran Pather
Jan 16, 2016·Nanomedicine : Nanotechnology, Biology, and Medicine·Monika KauravRavi Shankar Pandey
Dec 4, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·A L SilvaW Jiskoot
Jul 12, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Juliana De Souza RebouçasCarlos Gamazo
Jan 18, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·S B RizwanS Hook
Sep 28, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Suzanne M BalJoke A Bouwstra
Apr 27, 2010·International Journal of Pharmaceutics·Brian R SloatZhengrong Cui
Aug 15, 2015·Vaccine·Yufei XiaZhiguo Su
Dec 3, 2014·Advanced Drug Delivery Reviews·Nishant K JainC Russell Middaugh

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