Vaccine against arteriosclerosis: an update

Therapeutic Advances in Vaccines
Kuang-Yuh ChyuPrediman K Shah

Abstract

Substantial data from experimental and clinical investigation support the role of immune-mediated mechanisms in atherogenesis, with immune systems responding to many endogenous and exogenous antigens that play either proatherogenic or atheroprotective roles. An active immunization strategy against many of these antigens could potentially alter the natural history of atherosclerosis. This review mainly focuses on the important studies on the search for antigens that have been tested in vaccine formulations to reduce atherosclerosis in preclinical models. It will also address the opportunities and challenges associated with potential clinical application of this novel therapeutic paradigm.

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Citations

Mar 1, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Peter Libby, Brendan M Everett
Mar 15, 2019·Journal of Atherosclerosis and Thrombosis·Hiroyasu YamamotoShinji Kihara
Jul 19, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Florentina Porsch, Christoph J Binder
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May 25, 2021·Informatics in Medicine Unlocked·Amany A SarhanAhmed A Al-Karmalawy
Nov 16, 2021·International Reviews of Immunology·Azin AghamajidiNazanin Mojtabavi

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