Vaccine-associated Rubella - a report of two cases and a review of the literature.

Human Vaccines & Immunotherapeutics
Sean Wei Xiang OngKwai Peng Chan

Abstract

We report the clinical characteristics of two adult patients, presenting with a typical erythematous rash consistent with rubella disease after MMR vaccination. Both patients had an uncomplicated clinical course and recovered uneventfully. One patient was confirmed to have vaccine-associated rubella via sequencing of virus isolated in viral culture. The other patient had a pharyngeal swab positive for rubella virus PCR, with sequencing matching the vaccine strain. There are few reports of clinical disease from rubella vaccine-strains in the literature. Previous authors have reported severe disseminated vaccine-associated rubella in both immunodeficient and immunocompetent patients. Further study is required to ascertain the incidence, risk factors, and clinical characteristics of this condition; as well as investigate the extent of horizontal transmission to guide infection control recommendations.

References

May 1, 1982·The Journal of Infectious Diseases·G A LosonskyP L Ogra
Oct 12, 2000·Clinical Microbiology Reviews·J Y Lee, D S Bowden
Apr 6, 2004·Lancet·J E Banatvala, D W G Brown
Sep 26, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Stanley A Plotkin
Nov 13, 2013·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Felipe Augusto Souza GualbertoCristina Adelaide Figueiredo
Jul 30, 2014·Prenatal Diagnosis·Elise BouthryChristelle Vauloup-Fellous
Oct 24, 2018·Open Forum Infectious Diseases·Marta Gonzalez VicentMiguel Angel Diaz Perez

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Methods Mentioned

BETA
enzyme-linked
ELISA
PCR
Genotyping

Software Mentioned

MEGA

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