Vaccine coverage estimation using a computerized vaccination registry with potential underreporting and a seroprevalence study

Vaccine
Lina Pérez BrevaJoan Puig Barberà

Abstract

To develop a method to estimate vaccination coverage using both a computerized vaccine registry with an unknown underreporting rate and a seroprevalence study. A real example of a meningococcal C conjugate vaccine (MCCV) coverage estimation is studied to illustrate the proposed methodology. We reviewed the Vaccine Information System of Valencia (Sistema de Información Vacunal, SIV) for the MCCV status of 1430 subjects aged 3-29 years as part of a seroprevalence study. When MCCV was not registered in SIV, subjects were classified into three groups (MCCV non-registered, no vaccination records and missing information) depending on the registry of other vaccines. A Bayesian model was developed to ascertain the percentage of MCCV-vaccinated subjects based on the meningococcal C seroprotection levels from the seroprevalence study. The seroprotection levels in subjects with no MCCV registered in SIV (358) were similar to those in subjects with MCCV registered (1072). This indicated a large proportion of vaccinated subjects with no MCCV registered. The estimated vaccine coverage was over 80% in all age groups, except >22 years, where it was 67.6% (95% CI: [54.0-80.4]), which corresponded to those aged over 13 years at the time of the c...Continue Reading

References

Feb 15, 2003·BMJ : British Medical Journal·Mary E RamsayElizabeth Miller
Oct 2, 2008·Clinical and Vaccine Immunology : CVI·Caroline L TrotterElizabeth Miller
Apr 9, 2010·The Pediatric Infectious Disease Journal·Javier Diez-DomingoM Victoria Gutierrez-Gimeno
Jun 3, 2014·BMC Infectious Diseases·Lina Pérez-BrevaJavier Díez-Domingo

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Citations

Jun 25, 2016·Journal of Medical Internet Research·Cameron BellKumanan Wilson
Feb 28, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Travis LimFiona P Havers

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