Vaccine delivery carriers: insights and future perspectives

International Journal of Pharmaceutics
J F Correia-PintoM J Alonso

Abstract

Vaccination is undoubtedly the most effective health intervention for disease prevention and eradication. Nevertheless, currently there is still a need for improving immunization coverage worldwide. A promising strategy to achieve this goal nowadays relies on the use of delivery carriers capable of inducing an effective immune response and providing improved stability, safety and cost effectiveness. This article focuses on analyzing the critical aspects in the design of these carriers, and reviewing the state of the art of currently marketed formulations and those in advanced clinical development. These vaccine delivery carriers include emulsions, liposomes and polymeric particulate carriers. Finally, particular attention is given to the evolution in the design of polymeric nanocarriers, which have been receiving increasing attention and hold promise to generate novel platforms for needle-free administration and single-dose vaccination.

References

Dec 1, 1976·Journal of Pharmaceutical Sciences·G Birrenbach, P P Speiser
Jan 1, 1984·Journal of Pharmaceutical Sciences·M I ZapataS L Hem
Jan 1, 1994·Annual Review of Immunology·P Matzinger
Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·M Kovacsovics-BankowskiK L Rock
Jun 1, 1996·Journal of Pharmaceutical Sciences·A SanchezR Langer
Jun 6, 2000·Advanced Drug Delivery Reviews·E AllémannR Gurny
Jun 7, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·P JohansenB Gander
Jun 30, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·F R Vogel
Aug 8, 2001·Advanced Drug Delivery Reviews·M A Swartz
Nov 8, 2001·Journal of Drug Targeting·J BrookingL Illum
Jan 5, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·A VilaM J Alonso
Jul 5, 2003·International Journal of Pharmaceutics·A M CarcabosoJ L Pedraz
Aug 6, 2003·Expert Review of Vaccines·Derek T O'Hagan, Manmohan Singh
Dec 8, 1962·Nature·A D BANGHAMJ A LUCY
Jan 20, 2004·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Ana VilaMaría José Alonso
Jul 21, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ana VilaMaría José Alonso
Jul 23, 2004·Expert Opinion on Biological Therapy·Rajendra PawarAbraham J Domb
Aug 6, 2004·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·A VilaM J Alonso
Oct 27, 2004·Journal of Biomaterials Science. Polymer Edition·N CsabaM J Alonso
Nov 5, 2004·The New England Journal of Medicine·Richard T KenneyGregory M Glenn
Nov 25, 2004·Advanced Drug Delivery Reviews·Martin J Pearse, Debbie Drane
Jan 11, 2005·Biomacromolecules·Noémi CsabaMaría José Alonso
Jan 29, 2005·Journal of Liposome Research·Lee Leserman
Mar 22, 2005·International Journal of Pharmaceutics·Prem N GuptaSuresh P Vyas
Apr 7, 2005·Nature Medicine·Achal PashineJeffrey B Ulmer
Apr 7, 2005·Nature Medicine·Mark Larché, David C Wraith
May 3, 2005·Critical Reviews in Therapeutic Drug Carrier Systems·Vincent W Bramwell, Yvonne Perrie
May 3, 2005·Nature Reviews. Cancer·Richard A Lake, Bruce W S Robinson
Jun 14, 2005·Current Opinion in Immunology·Andreas Wack, Rino Rappuoli
Jun 18, 2005·International Journal of Pharmaceutics·Camilla FogedAnne Sundblad
Nov 22, 2005·Expert Opinion on Drug Delivery·Monjed ShakwehElias Fattal

❮ Previous
Next ❯

Citations

May 28, 2013·International Journal of Pharmaceutics·C ColonnaI Genta
Feb 20, 2013·Biologie aujourd'hui·Jose Vicente Gonzalez-AramundizMaría José Alonso
Dec 18, 2013·AAPS PharmSciTech·Chompoonuch SawaengsakNuttanan Sinchaipanid
Apr 22, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Simi MathewChristian Wischke
Mar 29, 2014·Nanomedicine·Sara VicenteMaria J Alonso
Jan 1, 2014·Vaccines·Weidang LiAshlesh K Murthy
Nov 28, 2013·Nanomedicine : Nanotechnology, Biology, and Medicine·Weibin ZhouFrançois Baneyx
Jan 12, 2016·Human Vaccines & Immunotherapeutics·A L SilvaW Jiskoot
Nov 26, 2015·International Journal of Pharmaceutics·Zahra KakhiBéatrice Heurtault
Dec 17, 2015·Pharmaceutical Patent Analyst·Ana S Cordeiro, María J Alonso
Oct 13, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·José Vicente González-AramundizNoemi Stefánia Csaba
Oct 13, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Jin Jau LiauTimothy J Barnes
Jun 7, 2015·Biotechnology Advances·Ana Sara CordeiroMaría de la Fuente
Jan 30, 2015·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Atul SrivastavaMeenakshi Iyer
Sep 4, 2015·Biomaterials Research·Jun YangXin Zhang
Apr 1, 2015·Future Microbiology·Ananda S BandyopadhyayWalter A Orenstein
Mar 22, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ankit MittalClaus-Michael Lehr
Dec 4, 2013·Vaccine·Liang ZhaoAnton P J Middelberg
Oct 31, 2016·Advanced Drug Delivery Reviews·Zeinab HosseinidoustMetin Sitti
Nov 22, 2016·Human Vaccines & Immunotherapeutics·Yimei JiaMichael J McCluskie
Apr 26, 2017·Nanomedicine·Olga KammonaCostas Kiparissides
Jan 18, 2016·Journal of Colloid and Interface Science·Jeong-Jun LeeHyun-Jong Cho
Feb 5, 2015·Clinical and Experimental Vaccine Research·Yong Taik Lim
Dec 28, 2018·Biotechnology & Genetic Engineering Reviews·Armando Tejeda-MansirPatricia Guerrero-Germán
Feb 11, 2020·Drug Delivery and Translational Research·Tamara G DacobaJosé Crecente-Campo
Feb 6, 2020·Malaria Journal·Jessica Molina-FrankyManuel Elkin Patarroyo
May 1, 2020·Frontiers in Chemistry·Shuyao Lang, Xuefei Huang
Sep 23, 2014·Cancer Prevention Research·Asad Umar
Nov 2, 2019·Immunology Letters·Miao LiHua-Ji Qiu
Mar 13, 2021·Advanced Drug Delivery Reviews·Carina PeresHelena F Florindo
Mar 27, 2021·Probiotics and Antimicrobial Proteins·Shima Moradi-KalbolandiLeila Farahmand
Apr 26, 2017·Advanced Drug Delivery Reviews·Julia E Vela RamirezNicholas A Peppas
Jul 28, 2021·Advanced Drug Delivery Reviews·Matilde Durán-LobatoMaría José Alonso
Oct 31, 2018·Molecular Pharmaceutics·José Vicente González-AramundizNoemi Stefánia Csaba

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Biologie aujourd'hui
Jose Vicente Gonzalez-AramundizM J Alonso
Immunologic Research
Yasmin Thanavala, Amit A Lugade
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
John K Chan, Jonathan S Berek
© 2021 Meta ULC. All rights reserved