PMID: 8378617Jul 1, 1993Paper

Vaccine-derived Pasteurella haemolytica alter the responses of ovine pulmonary artery and vein to drugs acting on adenylate cyclase

Research in Veterinary Science
L B WeekleyN Sriranganathan

Abstract

Sheep were vaccinated with a live, vaccine-derived strain of Pasteurella haemolytica. The ex vivo response of isolated pulmonary artery and vein to isoproterenol, cholera toxin, sodium fluoride and calcium were examined three days after vaccination. In the pulmonary artery (endothelium intact), vaccination did not alter the response to isoproterenol, or sodium fluoride whereas the relaxation response to cholera toxin was impaired. In the pulmonary artery (endothelium removed), the maximum relaxation attained in response to isoproterenol was reduced and the response to exogenous calcium, sodium fluoride and cholera toxin not altered. In the pulmonary vein (endothelium intact), the response to isoproterenol and sodium fluoride was unchanged whereas the response to cholera toxin was impaired. In the pulmonary vein (endothelium removed), the response to isoproterenol and sodium fluoride was not altered following P haemolytica vaccination whereas the relaxation response to cholera toxin was enhanced and the response to exogenous calcium slightly impaired. These experiments suggest that vaccination with live strains of P haemolytica cause subclinical disturbances in the pulmonary circulation and may potentially alter the animals' res...Continue Reading

References

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Citations

Jul 22, 2010·Journal of Veterinary Pharmacology and Therapeutics·T P LaBrancheP Eyre
Feb 1, 1993·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·L B Weekley
Jun 13, 2003·Journal of Advanced Nursing·Marit Helene Hem, Kristin Heggen

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