Vaccine effectiveness following routine immunization with bivalent HPV vaccine: Protection against incident genital HPV infections from a reduced-dosing schedule.

The Journal of Infectious Diseases
Joske HoesHester de Melker

Abstract

In the Netherlands, the bivalent HPV vaccine (2vHPV) has been offered to preadolescent girls via the National Immunization Program (NIP) in a two-dose (2D) schedule since 2014. The current study estimates vaccine effectiveness (VE) against HPV infections up to four years post-vaccination among girls eligible for routine 2D immunization. A cohort study (HAVANA2) was used in which participants annually filled out an online questionnaire and provided a vaginal self-sample for determination of HPV by the SPF10-LiPA25 assay, able to detect 25 HPV types. VE against incident type-specific infections and pooled outcomes was estimated by a Cox proportional hazards model with shared frailty between the HPV types. In total, 2027 girls were included in the study, 1098 (54.2%) of whom were vaccinated with two doses. Highest incidence rate was 5.0/1000 person-years (HPV51) among vaccinated participants and 9.1/1000 person-years (HPV74) among unvaccinated participants. Adjusted pooled VE was 84.0% (95%CI, 27.0-96.5%) against incident HPV16/18 infections and 86.5% (95%CI, 39.5-97.08%) against cross-protective types HPV31/33/45. Four years post-vaccination, two doses of 2vHPV vaccination were effective in the prevention of incident HPV16/18 inf...Continue Reading

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