Vaccine-elicited memory cytotoxic T lymphocytes contribute to Mamu-A*01-associated control of simian/human immunodeficiency virus 89.6P replication in rhesus monkeys

Journal of Virology
Michael S SeamanNorman L Letvin


The expression of particular major histocompatibility complex (MHC) class I alleles can influence the rate of disease progression following lentiviral infections. This effect is a presumed consequence of potent cytotoxic T-lymphocyte (CTL) responses that are restricted by these MHC class I molecules. The present studies have examined the impact of the MHC class I allele Mamu-A*01 on simian/human immunodeficiency virus 89.6P (SHIV-89.6P) infection in unvaccinated and vaccinated rhesus monkeys by exploring the contribution of dominant-epitope specific CTL in this setting. Expression of Mamu-A*01 in immunologically naive monkeys was not associated with improved control of viral replication, CD4+ T-lymphocyte loss, or survival. In contrast, Mamu-A*01+ monkeys that had received heterologous prime/boost immunizations prior to challenge maintained higher CD4+ T-lymphocyte levels and better control of SHIV-89.6P replication than Mamu-A*01- monkeys. This protection was associated with the evolution of high-frequency anamnestic CTL responses specific for a dominant Mamu-A*01-restricted Gag epitope following infection. These data indicate that specific MHC class I alleles can confer protection in the setting of a pathogenic SHIV infection...Continue Reading


Mar 12, 1999·Science·M CarringtonS J O'Brien
Mar 1, 2000·Proceedings of the National Academy of Sciences of the United States of America·S A MiguelesM Connors
Oct 12, 2000·Nature·E S RosenbergB D Walker
Apr 3, 2001·Science·D Paydarfar, W J Schwartz
Apr 16, 2002·AIDS·Geraldine M A GillespieSarah L Rowland-Jones
Sep 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Thorsten MühlUlrike Sauermann
Jun 29, 2004·Journal of Virology·Norman L LetvinGary J Nabel
Jul 20, 2004·Proceedings of the National Academy of Sciences of the United States of America·Sampa SantraNorman L Letvin
Aug 7, 2004·Proceedings of the National Academy of Sciences of the United States of America·Yoshiaki NishimuraMalcolm A Martin


Sep 29, 1979·Biochimica Et Biophysica Acta·G Rakhit, C F Chignell
Jan 1, 2014·Vaccines·Barbara K FelberGeorge N Pavlakis
Aug 19, 2007·Seminars in Cell & Developmental Biology·Matthew J Paul, Lorenzo Frigerio
Mar 10, 2016·Molecular Therapy. Methods & Clinical Development·Christopher W PetersonHans-Peter Kiem
Jul 1, 2006·Current Opinion in HIV and AIDS·Patricia E Fast
Jan 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kenji SomeyaMitsuo Honda
Apr 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paula M AciernoNorman L Letvin
Nov 5, 2008·Expert Review of Vaccines·Silvia BaroncelliAndrea Cara

Related Concepts

Mamu-A 01 antigen
Immunologic Memory
Macaca mulatta
RNA, Viral
TC2 Cells
Virus Replication
Simian immunodeficiency virus
Human Class I Antigens
CD4 Positive T Lymphocytes

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.