Vaccine engineering improved by hybrid technology

International Archives of Allergy and Immunology
Birgit Linhart, Rudolf Valenta

Abstract

The term 'vaccination' describes the induction of protective immune responses against infectious diseases, but is also used to define antigen-specific forms of immunotherapy for allergy, cancer and autoimmunity. Successful vaccination requires either immune modulation or the induction of robust specific immunity to several disease-causing antigens. However, natural antigen sources may contain greatly varying amounts of these antigens and some of them may exhibit low immunogenicity. An approach for overcoming the latter problems has been developed for allergy vaccines recently. This approach is based on the genetic engineering of hybrid molecules, consisting of several major disease-eliciting antigens/epitopes. Such hybrid molecules can be built to include the most relevant epitopes of complex antigen sources. Moreover, fusion of different antigens in the form of hybrid molecules strongly increases their immunogenicity. The hybrid approach can also be used for the generation of mosaic antigens with altered immunological properties, which consist of re-shuffled antigen pieces. We exemplify the use of hybrid technology for the generation of new allergy vaccines and discuss its potential applicability for the development of vaccine...Continue Reading

Citations

Feb 4, 2009·Clinical and Molecular Allergy : CMA·Ruby TiwariMohan B Singh
May 27, 2014·Current Treatment Options in Allergy·Katharina MarthVerena Niederberger
Jan 29, 2008·Trends in Biotechnology·Prem L Bhalla, Mohan B Singh
Jun 15, 2007·The Journal of Allergy and Clinical Immunology·Roberto González-RiojaJuan A Asturias
Mar 6, 2007·The Journal of Allergy and Clinical Immunology·Rudolf Valenta, Verena Niederberger
May 17, 2006·Immunology and Allergy Clinics of North America·Oliver CromwellAnnemie Narkus
Apr 30, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J A AsturiasA Martínez
May 30, 2012·Journal of Internal Medicine·R ValentaM van Hage
Mar 10, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M FockeR Valenta
Apr 29, 2006·La Revue de médecine interne·G Kanny, S Jacquenet
Oct 19, 2005·Current Opinion in Immunology·Birgit Linhart, Rudolf Valenta
Oct 12, 2004·Immunology and Allergy Clinics of North America·Verena Niederberger, Rudolf Valenta
May 4, 2017·International Archives of Allergy and Immunology·Angelika Tscheppe, Heimo Breiteneder
Mar 31, 2015·International Journal of Immunopathology and Pharmacology·B BarlettaG Di Felice
Jan 11, 2005·Current Opinion in Allergy and Clinical Immunology·Verena Niederberger, Rudolf Valenta
Jan 9, 2020·Expert Opinion on Therapeutic Patents·Eduardo Santos da SilvaNeuza Maria Alcantara-Neves
Aug 14, 2012·Current Opinion in Allergy and Clinical Immunology·Margarete Focke-Tejkl, Rudolf Valenta
Dec 9, 2015·The Journal of Biological Chemistry·Judith A WoodfolkAnna Pomés
Jan 31, 2019·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Paolo Maria MatricardiHarald Renz
Jul 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Susanne VrtalaRudolf Valenta
Jun 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ulrike BaranyiThomas Wekerle

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.