Vaccine Immunotherapy for Celiac Disease

Frontiers in Medicine
Antonio Di SabatinoCarmen Gianfrani

Abstract

Autoimmune and allergic disorders are highly prevalent conditions in which an altered or abnormal immune response is mounted against self- or environmental antigens, respectively. Antigen-based immunotherapy is a therapeutic option aimed at restoring the specific immune tolerance toward pathogenic antigens while leaving the rest of the immune system unaffected. This strategy proved efficacy especially in allergic diseases, including asthma, allergic rhinitis, and food allergies, but still has shortcomings for the treatment of autoimmune diseases. However, there are no available therapies, currently, in clinical practice for restoring the physiological tolerance that is typically lost in autoimmune diseases. In celiac disease, which is a common immune-mediated enteropathy triggered by the ingestion of gluten in genetically susceptible individuals, antigen-based immunotherapy could be a feasible option thanks to our deep understanding of the pathogenic mechanisms underpinning this condition. In fact, the immunodominant gluten epitopes are well-characterized and are recognized by pathogenic CD4+ T-cells that could be desensitized with immunotherapy. Moreover, the intestinal damage occurring in celiac disease (i.e., villous atrophy...Continue Reading

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Citations

Mar 23, 2019·Human Vaccines & Immunotherapeutics·Willem van Eden
Mar 16, 2019·Journal of Clinical Pathology·Marco Vincenzo Lenti, Gino Roberto Corazza
Jul 18, 2019·Expert Opinion on Drug Discovery·Luis VaqueroSantiago Vivas
Mar 23, 2019·Italian Journal of Pediatrics·Luigi MaiuriGuido Kroemer
Feb 10, 2019·Cell Death & Disease·Luigi MaiuriGuido Kroemer
Sep 6, 2020·Current Opinion in Gastroenterology·Robert P Anderson
Mar 16, 2021·Frontiers in Immunology·Javier Sanchez-SolaresCristina Gomez-Casado

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Methods Mentioned

BETA
biopsy

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