Vaccine-induced antigen-specific regulatory T cells attenuate the antiviral immunity against acute influenza virus infection

Mucosal Immunology
Pin-Hung LinHung-Chih Yang

Abstract

Peptide-based T cell vaccines targeting the conserved epitopes of influenza virus can provide cross-protection against distantly related strains, but they are generally not immunogenic. Foreign antigen-specific regulatory T (Treg) cells are induced under subimmunogenic conditions peripherally, although their development and role in vaccine-mediated antiviral immunity is unclear. Here, we demonstrated primary vaccination with peptides alone significantly induced antigen-specific Foxp3+ Treg cells, which were further expanded by repeated vaccination with unadjuvanted peptides. Certain adjuvants, including CpG, suppressed the induction and expansion of antigen-specific Treg cells by peptide vaccination. Interestingly, secondary influenza virus infection significantly increased the frequency of preexisting antigen-specific Treg cells, although primary infection barely induced them. Importantly, specific depletion of vaccine-induced antigen-specific Treg cells promoted influenza viral clearance, indicating their inhibitory role in vivo. Immunization with CpG-adjuvanted peptides by the subcutaneous prime-intranasal-boost strategy restricted the recruitment and accumulation of antigen-specific Treg cells in lung, and stimulated robust...Continue Reading

References

Oct 1, 1983·Lancet·A J McMichaelC W Potter
Jul 14, 2001·Science·R M Zinkernagel, H Hengartner
Sep 17, 2003·The Journal of Experimental Medicine·Susmit SuvasBarry T Rouse
Aug 27, 2005·Science·Guangyong PengRong-Fu Wang
Oct 26, 2005·Nature Immunology·Karsten KretschmerHarald von Boehmer
Feb 24, 2006·Emerging Infectious Diseases·Paul G ThomasPeter C Doherty
Jan 4, 2007·The Journal of Experimental Medicine·Katharina LahlTim Sparwasser
May 31, 2008·Cell·Shimon SakaguchiMasahiro Ono
Feb 28, 2009·Nature Reviews. Immunology·Philippa MarrackMichael W Munks
Oct 30, 2010·Immunity·Robert L CoffmanRobert A Seder
Feb 3, 2011·Methods in Molecular Biology·Barbara Fazekas de St GrothLoretta Lee
Oct 19, 2011·Journal of Biomedicine & Biotechnology·Bruno GarulliMaria R Castrucci
Nov 8, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·John R TeijaroDonna L Farber
Jan 10, 2012·Annual Review of Immunology·Steven Z JosefowiczAlexander Y Rudensky
Feb 10, 2012·Journal of Clinical Immunology·Jacob AtsmonTamar Ben-Yedidia
Aug 3, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ana M SanchezYiping Yang
Mar 8, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Erik L BrincksDavid L Woodland
Mar 20, 2013·Nature Immunology·Abul K AbbasSteve F Ziegler
Jun 12, 2013·Frontiers in Immunology·Fabio FiorinoAnnalisa Ciabattini
Aug 24, 2013·Frontiers in Immunology·Chantal KeijzerFemke Broere
Sep 24, 2013·Nature Medicine·Saranya SridharAjit Lalvani
May 6, 2014·Frontiers in Immunology·Sietske Rosendahl HuberDebbie van Baarle
Feb 19, 2015·Human Vaccines & Immunotherapeutics·Andrea A TimothyPhilip Sutton
Mar 15, 2015·Cell Host & Microbe·Katherine Houser, Kanta Subbarao

❮ Previous
Next ❯

Citations

May 23, 2019·Immunology and Cell Biology·Chunni LuWeisan Chen
Oct 15, 2019·Journal of Thrombosis and Haemostasis : JTH·Bryn M SmithCarol H Miao
Jul 18, 2019·Immunity & Ageing : I & a·I Herrero-FernándezY M Pacheco
Mar 22, 2019·Frontiers in Immunology·Naomi R TruongAnthony L Cunningham
Apr 23, 2020·Mucosal Immunology·Jake DunningPeter J M Openshaw
Sep 13, 2019·AIDS Research and Human Retroviruses·Farouk Abou HassanNada M Melhem
Apr 27, 2021·Molecular Therapy. Methods & Clinical Development·Pin-Hung LinHung-Chih Yang
Jun 12, 2021·Frontiers in Immunology·Joo Guan YeoSalvatore Albani
Jun 25, 2021·International Immunopharmacology·Alexander Batista-DuharteRafael Solana
Jul 10, 2021·Mucosal Immunology·Ruth I ConnorPeter F Wright
Jun 22, 2021·The Journal of Allergy and Clinical Immunology·Kirstin JansenMübeccel Akdis

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
flow cytometry

Software Mentioned

FlowJo
FACS

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.