Vaccine-induced IgG2 anti-HIV p24 is associated with control of HIV in patients with a 'high-affinity' FcgammaRIIa genotype

AIDS
Martyn A FrenchSean Emery

Abstract

We have previously shown that vaccination with a recombinant fowlpox virus carrying the genes for HIV Gag-Pol and interferon-gamma (IFN-gamma) was associated with partial control of HIV replication after antiretroviral therapy (ART) was ceased but not with increased anti-HIV T-cell responses. Because IFN-gamma enhances IgG2 production, and IgG2 antibodies to HIV antigens and the 'high-affinity' polymorphism of FcgammaRIIa (the major Fc receptor for IgG2) have been associated with a favourable outcome of HIV infection, we examined the association of IgG2 antibodies to HIV p24 and 'high-affinity' polymorphisms of FcgammaRIIa with control of HIV replication in these patients. Plasma from weeks 0 (cessation of ART 1 week after the last vaccination), 9 and 20 was available from patients who had received the full construct vaccine, a partial construct (without IFN-gamma) or placebo. IgG2 and IgG1 anti-p24 and anti-gp41 were assayed and all patients were genotyped for the FcgammaRIIa 131 R/H polymorphism that affects IgG2 binding. At week 0, IgG2 anti-p24 was present in five of nine full construct patients but none of 14 partial construct or placebo patients and was associated with a smaller increase in plasma HIV RNA over 20 weeks. P...Continue Reading

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Citations

Mar 29, 2014·Current Opinion in HIV and AIDS·Sarah L Cocklin, Joern E Schmitz
Nov 15, 2011·Annual Review of Medicine·Margaret E AckermanGalit Alter
Jun 11, 2014·Immunology and Cell Biology·Fernanda Ana-Sosa-BatizMarit Kramski
Nov 28, 2015·Open Forum Infectious Diseases·Caitlin MilliganJulie Overbaugh
Jul 6, 2014·Frontiers in Immunology·Bin Su, Christiane Moog
Aug 30, 2014·The Journal of Infectious Diseases·Vijaya MadhaviStephen J Kent
Oct 27, 2015·Immunological Reviews·Austin W BoeschMargaret E Ackerman
Aug 24, 2017·Retrovirology·Miguel de MulderHenri-Alexandre Michaud
Apr 26, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·M Christian TjiamMartyn A French
May 26, 2018·The Journal of Experimental Medicine·Claus KadelkaUNKNOWN Swiss HIV Cohort Study
Apr 4, 2019·Frontiers in Immunology·Jessica C AnaniaP Mark Hogarth
Dec 18, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Halina M TristP Mark Hogarth
Oct 17, 2020·ImmunoTargets and Therapy·Henok AndualemWasihun Hailemichael
Feb 2, 2016·Advanced Drug Delivery Reviews·Casey K Hua, Margaret E Ackerman

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